I-β-Nicotinamide Mononucleotide CAS:1094-61-7

I-β-Nicotinamide mononucleotide (NMN) isetshenziselwa ukutadisha ama-motif okubopha ngaphakathi kwama-aptamers e-RNA kanye nezinqubo zokuqalisa ukusebenza kwe-ribozyme ezibandakanya izingcezu ze-RNA ezisebenza nge-β-nicotinamide mononucleotide (β-NMN). I-NMN iyi-nucleotide etholakala ku-ribose kanye ne-nicotinamide. I-Niacinamide (nicotinamide,) iyi-derivative ye-vitamin B3, eyaziwa nangokuthi i-niacin.) Njengesandulela se-biochemical se-NAD+, ingaba usizo ekuvimbeleni i-pellagra.
I-β-Nicotinamide mononucleotide iyingxenye ebalulekile ekuhlanganisweni kwe-nicotinamide adenine dinucleotide (NAD+). I-Nicotinamide phosphoribosyltransferase (Nampt) ikhuthaza ukujiya kwe-nicotinamide nge-5-phosphoribosyl-1-pyrophosphate ukuze ikhiqize i-β-NMN, kamuva eguqulwa ibe yi-NAD+ yi-β-NMN adenyltransferase. Ku-50-100 μM, i-β-NMN isetshenziswe ukuthuthukisa ukuhlanganiswa kwe-NAD kanye nokukhiqizwa kwe-insulin okuvuselelwe yi-glucose kumodeli yegundane le-Nampt+/- yesifo se-metabolic, okubonisa indima ye-Nampt ekusebenzeni kweseli le-β.