I-Vitamin B3 (i-Nicotinic Acid/i-Niacin) I-CAS:59-67-6

I-Niacin isetshenziswa kabanzi ezithasiseleni zokudla kanye nezindlela zokudla okunempilo ukusekela impilo yenhliziyo, i-lipid metabolism, kanye nomsebenzi wokujikeleza kwegazi jikelele. Njengesandulela se-coenzymes i-nicotinamide adenine dinucleotide (NAD) kanye ne-nicotinamide adenine dinucleotide phosphate (NADP), i-niacin ibamba iqhaza ezindleleni eziningi ze-metabolic, isiza ekuguqulweni kwezakhamzimba zibe amandla futhi inegalelo ekuphefumuleni kwamaseli kanye nokwakheka kwe-ATP. Ngakho-ke, ifakwa ezithasiseleni ezihlose impilo yenhliziyo, ukuphathwa kwe-cholesterol, kanye nokukhiqizwa kwamandla. Ngaphezu kwendima yayo ekusetshenzisweni kwamandla, i-niacin iye yaqashelwa ngamandla ayo okusekela amaphrofayili e-lipid anempilo ngokukhuthaza amazinga e-cholesterol alinganiselayo. Isetshenziswa ezithasiseleni zokudla ezenzelwe ukubhekana nezinkinga ezithile zenhliziyo ezihlobene ne-lipid metabolism, njengokusekela amazinga e-triglyceride anempilo kanye nokwenza ngcono izilinganiso ze-cholesterol emzimbeni. Ngaphezu kwalokho, i-niacin isetshenziswa embonini yezemithi ngezinzuzo zayo ezingaba khona ekubhekaneni nezimo ezithile zempilo, kufaka phakathi i-pellagra kanye nezinkinga ezithile ezihlobene ne-lipid. Ukusetshenziswa kwayo emithini yezokwelapha kungabandakanya ukwelashwa kokuntuleka kwe-niacin kanye nokuphathwa okwengeziwe kwe-hyperlipidemia ngaphansi kwesiqondiso sochwepheshe bezempilo. Ngaphezu kwalokho, i-niacin isetshenziswa embonini yokudla ngezinjongo zokuqinisa ukuze kuthuthukiswe okuqukethwe okunomsoco kwemikhiqizo yokudla ehlukahlukene, okufaka isandla emizamweni yezempilo yomphakathi ehlose ukunciphisa ukuntuleka kwezakhamzimba ezincane. Ukufakwa kwayo ekudleni okuqinisiwe kusekela ukuhlinzekwa kwamavithamini B abalulekile kubantu abasengozini yokungadli i-niacin ngokwanele, ngaleyo ndlela kuthuthukiswe ukwanela kwezakhamzimba kanye nokuphila kahle. Sekukonke, ukusetshenziswa kwe-niacin okuguquguqukayo ekungezeleleni kokudla, ukuqinisa ukudla, kanye nemithi kugcizelela ukubaluleka kwayo njengesakhamzimba esiyisisekelo esisekela impilo yenhliziyo nemithambo yegazi, umsebenzi we-metabolic, kanye nenhlalakahle iyonke ngokusekelwe ekuqondeni kwesayensi kwamanje kanye nemikhuba yemboni.