I-Vitamin B13 (i-Orotic Acid) I-CAS: 65-86-1 Umkhiqizi Umhlinzeki Isithombe Esivelele

I-Vitamin B13 (i-Orotic Acid) I-CAS: 65-86-1 Umhlinzeki Womkhiqizi

I-Orotic acid (eyaziwa nangokuthi i-pyrimidinecarboxylic acid) iyi-heterocyclic acid; yaziwa nangokuthi. Ngokomlando yayikholelwa ukuthi iyingxenye ye-vitamin B complex futhi yayibizwa ngokuthi i-vitamin B13, kodwa manje sekuyaziwa ukuthi ayiyona i-vitamin. Yaziwa kakhulu njengesandulela se-biosynthesis yama-pyrimidines; ezincelisayo ikhishwa ku-mitochondrial dihydroorotate dehydrogenase (DHODH) ukuze iguqulwe ibe yi-UMP yi-cytoplasmic UMP synthase enzyme. I-OA nayo iyingxenye evamile yokudla, itholakala obisini nasemikhiqizweni yobisi, futhi iguqulwa ibe yi-uridine ukuze isetshenziswe endleleni ye-pyrimidine salvage ikakhulukazi esibindini, ezinso kanye nakuma-erythrocyte.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

I-Orotic acid iyi-intermediate in de novo pyrimidine biosynthesis engasetshenziswa ukutadisha ukucaciswa kanye ne-kinetics ye-orotate phosphoribosyltransferase (OPRT) ekhuthaza ukudluliselwa kwe-phosphoribosyl okuguquguqukayo kusuka ku-5?-phospho-α-d-ribose 1?-diphosphate (PRPP) kuya ku-orotic acid (OA), okwakha i-pyrophosphate kanye ne-orotidine 5?-monophosphate (OMP). Isetshenziswa njengento yokuqala yokukhiqizwa kwe-uridine 5?-monophosphate (UMP) ngamagciwane anjengeCorynebacterium ammoniagenes (ATCC 6872) noma i-Saccharomyces cerevisiae. Ingasetshenziswa ukutadisha indlela yokubonisana kweseli encike ku-AMPK/SREBP-1 kanye nezindlela zokulawula ukuqoshwa kwe-transcription ezibangela i-hepatic lipogenesis.

Isampula Yomkhiqizo

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C5H4N2O4
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe
Inombolo ye-CAS	65-86-1
Ukupakisha	25KG
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.