Usawoti we-trisodium we-Uridine-5′-diphosphoglucuronic acid CAS:63700-19-6

Ukususa ubuthi emzimbeni: I-UDP-glucuronic acid iyi-molecule ebalulekile ehilelekile ekuphenduleni kwe-biotransformation kwesigaba sesi-2 sama-xenobiotics kanye nama-compounds angaphandle. Isebenza njengesandulela sokwenziwa kwama-glucuronides, angama-conjugates ancibilika emanzini angasuswa kalula emzimbeni. Le nqubo yokususa ubuthi emzimbeni isiza ekunciphiseni nasekuqedeni izinto ezingaba yingozi, njengezidakamizwa, ubuthi bemvelo, kanye neminye imikhiqizo ebangela ukwakheka komzimba.

Ukuguqulwa kwemithi: Imithi eminingi idlula ku-glucuronidation, inqubo lapho i-UDP-glucuronic acid ihlangana khona ne-molecule yemithi, okuholela ekwakhekeni kwe-metabolite ye-glucuronide. Lokhu kusabela kwe-glucuronidation kuvame ukuthuthukisa ukukhishwa kwemithi emzimbeni futhi kusiza ekukhishweni kwayo ngomchamo noma nge-bile. Usawoti we-UDP-glucuronic acid trisodium uvame ukusetshenziswa ezifundweni ezihlola ukwakheka kwemithi kanye ne-pharmacokinetics yemithi.

Ithuluzi lokucwaninga: I-UDP-glucuronic acid Usawoti we-trisodium usetshenziswa kabanzi njengethuluzi lokucwaninga ezifundweni ezahlukahlukene ezihlobene nokusetshenziswa kwemithi, i-enzymology, kanye ne-toxicology. Ihlinzeka ngomthombo we-UDP-glucuronic acid wokuhlolwa kwe-in vitro futhi ivumela abacwaningi ukuthi baphenye umthelela we-glucuronidation ekususweni kwemithi, ukutholakala kwe-bioavailability, kanye nokusebenzisana okungenzeka phakathi kwemithi nemithi.

I-Glycosylation: I-UDP-glucuronic acid nayo ihilelekile ekuphenduleni kwe-glycosylation, lapho isebenza njengomnikeli wezingxenye ze-glucuronic acid zokwenziwa kwama-glycosaminoglycans (ama-GAG) nama-proteoglycans. Lawa ma-molecule anendima ebalulekile ezinqubweni ezahlukahlukene zebhayoloji, okuhlanganisa ukunamathela kwamaseli, ukwakheka kwe-extracellular matrix, kanye nokubonisa izimpawu.