I-Tofacitinib CAS:477600-75-2 Isithombe Esifakiwe Somhlinzeki Womkhiqizi

I-Tofacitinib CAS:477600-75-2 Umkhiqizi Supplier

I-Tofacitinib iyi-molecule yokuqala encane ye-kinase inhibitor evunyelwe ukwelashwa kwe-RA.I-Tofacitinib iyi-inhibitor ye-subtypes emine ye-Janus kinase (JAK): i-JAK1, i-JAK2, i-JAK3, ne-Tyk2.I-Tofacitinib yenza ngokuvimbela i-phosphorylation nokusebenza kwama-transducers esignali kanye nama-activator of transcription (STATs), ngaleyo ndlela icindezela abalamuleli abavuthayo. esicutshini esihlangene.

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Isicelo kanye Nomphumela

I-Tofacitinib iyisidakamizwa sokwelapha i-rheumatoid arthritis (RA), i-psoriasis, isifo samathumbu esivuvukalayo, nezinye izifo ze-immunological, kanye nokuvimbela ukwenqatshwa kokufakelwa kwezitho zomzimba.Kuyi-inhibitor ye-enzyme i-Janus kinase 3 (JAK3), okusho ukuthi iphazamisa indlela yokusayina ye-JAK-STAT edlulisela ulwazi ngaphandle kweseli ku-nucleus yeseli, okunomthelela ekulotshweni kwe-DNA.Muva nje kuboniswe kumodeli we-murine we-arthritis esungulwe, isifo se-tofacitinib esithuthukisiwe ngokushesha ngokuvimbela ukukhiqizwa kwabalamuleli abavuthayo kanye nokucindezela izakhi zofuzo ezincike ku-STAT1 ezicutshini ezihlangene. izindlela, okuphakamisa ukuthi i-tofacitinib ingase isebenzise inzuzo yokwelapha ngezindlela ezingagcini nje ngokuvinjelwa kwe-JAK3.

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Ulwazi Olwengeziwe:

Ukwakheka	I-C16H20N6O
Isivivinyo	99%
Ukubukeka	Impushana emhlophe
Inombolo ye-CAS.	477600-75-2
Ukupakisha	25KG
I-Shelf Life	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	ISO.