I-Tetrabenzyl Dapagliflozin CAS:2001088-28-2

I-tetrabenzyl dapagliflozin, eyakhiwe ngezindlela ezikhethekile zezinto eziphilayo, inokwakheka okuyinkimbinkimbi kwama-molecule okubalulekile ekusetshenzisweni kwayo okuhlukahlukene. Ukuba khona kwezinto ezine ezithatha indawo ye-benzyl engxenyeni ye-dapagliflozin kuthonya ukusabela kwayo kwamakhemikhali, ukuncibilika, kanye nokusebenzisana nezinhlelo zezinto eziphilayo. Lezi zici zesakhiwo zibalulekile ekuqondeni iphrofayili yayo yezokwelapha kanye namandla okwelapha. Ukusetshenziswa Kwemithi Le khompawundi inesithembiso ocwaningweni lwemithi ngenxa yokwakheka kwayo. Ama-derivatives e-Dapagliflozin, aziwa ngendima yawo njenge-sodium-glucose co-transporter 2 (SGLT2), asetshenziswa ekwelapheni isifo sikashukela sohlobo 2. Ukufakwa esikhundleni kwe-benzyl ku-tetrabenzyl dapagliflozin kungashintsha izakhiwo zayo ze-pharmacokinetic noma kuthuthukise ukukhetha kwayo kanye nokusebenza kwayo njenge-inhibitor ye-SGLT2. Umsebenzi Wezinto Eziphilayo Nezindlela Izifundo ziphakamisa ukuthi i-dapagliflozin kanye ne-derivatives yayo inemiphumela yayo yokwelapha ngokuvimbela i-SGLT2 kuma-tubules e-proximal ezinso, ngaleyo ndlela kuncishiswe ukumuncwa kabusha kwe-glucose ezinso futhi kwandise ukuphuma kwe-glucose emchameni. Amaqembu e-benzyl ku-tetrabenzyl dapagliflozin angathonya amandla ayo, ukuzinza kwe-metabolic, noma ukusebenzisana nama-receptor angaqondile, okuthinta iphrofayili yayo yezokwelapha iyonke. Izindlela Zokwenziwa Nokuthuthukiswa Ukwenziwa kwe-tetrabenzyl dapagliflozin kuhilela izinqubo eziyinkimbinkimbi zezinto eziphilayo eziqala ku-dapagliflozin kanye ne-benzyl halides noma i-benzyl alcohols. Ukwenza ngcono izindlela zokwenziwa kubalulekile ekufinyeleleni ubumsulwa obuphezulu kanye nezithelo, ezibalulekile ekusetshenzisweni kwemithi. Ngaphezu kwalokho, ukulungisa izindlela zokwenziwa kuthuthukisa ukuguquguquka, ukusebenza kahle kwezindleko, kanye nokusimama ekukhiqizweni kwemithi. Ucwaningo Lwamanje Neziqondiso Zesikhathi Esizayo Imizamo yocwaningo lwamanje igxile ekuhloleni amandla e-tetrabenzyl dapagliflozin ngale kokwelashwa kwesifo sikashukela, okuhlanganisa ukusetshenziswa kwayo ezifweni zenhliziyo noma ezinkingeni ze-metabolic. Izifundo zesikhathi esizayo zingase ziphenye ukuguqulwa kwesakhiwo sayo ukuze kuthuthukiswe ukutholakala kwezinto eziphilayo, kuncishiswe imiphumela emibi, noma kuqondiswe ezindleleni zokwelapha ezengeziwe. Izivivinyo zemitholampilo kanye nezifundo zangaphambi kokwelashwa ziyaqhubeka ukuhlola ukuphepha kwayo, ukusebenza kahle, kanye nemiphumela yesikhathi eside. Isiphetho Ekuphetheni, i-tetrabenzyl dapagliflozin imelela inhlanganisela ephawulekayo kumakhemikhali ezokwelapha kanye nocwaningo lwemithi ngenxa yesakhiwo sayo samakhemikhali esihlukile kanye nezicelo zokwelapha ezingaba khona. Ukufakwa kwamaqembu amane e-benzyl ohlakeni lwe-dapagliflozin kugqamisa ukuguquguquka kwayo kanye nesithembiso sayo semithi, ikakhulukazi ezifweni ezifana nesifo sikashukela sohlobo 2. Ukuqhubekisela phambili ucwaningo ngezakhiwo zayo zamakhemikhali, ukusebenzisana kwezinto eziphilayo, kanye nezindlela zokwenziwa kubalulekile ekwandiseni amandla ayo okwelapha kanye nokwandisa ukusetshenziswa kwayo kwezokwelapha.