I-Sodium Alpha-Ketoisocaproate CAS:4502-00-5 Umhlinzeki Womkhiqizi

I-Sodium Alpha-Ketoisocaproate iyi-metabolite ye-leucine eyaziwa ngokubangela ukukhishwa kwe-insulin kuma-βcell e-pancreas. Ukufakwa kwe-aα-Ketoisocaproate engaphakathi kutholakala kuthuthukisa isimo se-endotoxemia. Imizimba ye-ketone etholakala ngokuguqulwa kwayo, ingasebenza njengomthombo wamandla. Ukuqongelela kwe-α-Ketoisocaproic acid kubonakala ku-branched chain ketoaciduria, ebangelwa ukuntuleka komsebenzi we-branched chain L-2-keto acid dehydrogenase. I-α-Ketoisocaproic acid ibangela ukuhlukana ekusabeleni kwe-oxidative phosphorylation futhi isebenza njengesivimbeli se-metabolic se-α-ketoglutarate dehydrogenase. Ngakho-ke, kuholela ephutheni ku-homeostasis ye-mitochondrial, ebonakala ku-branched chain ketoaciduria.