I-Sodium Alpha-Ketoisocaproate CAS:4502-00-5 Umkhiqizi Womhlinzeki

I-Sodium Alpha-Ketoisocaproate iyi-metabolite ye-leucine eyaziwa ngokudala ukukhishwa kwe-insulin kuma-βcell we-pancreas.Ukufakwa kwangaphakathi kwe-aα-Ketoisocaproate kutholakala ukuze kuthuthukise, isimo se-endotoxemic.Imizimba ye-ketone ewumphumela etholwe ekuguqulweni kwayo, ingase isebenze njengomthombo wamandla.Ukuqoqwa kwe-α-Ketoisocaproic acid kubonakala ku-ketoaciduria ye-branched chain, ebangelwa ukuntuleka komsebenzi we-branched chain L-2-keto acid dehydrogenase.I-α-Ketoisocaproic acid ibangela ukuhlukaniswa kwe-oxidative phosphorylation reaction futhi isebenza njenge-inhibitor ye-metabolic ye-α-ketoglutarate dehydrogenase.Ngakho-ke, kuholela kusici ku-homeostasis ye-mitochondrial, ebonwa ku-branched chain ketoaciduria.