(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine CAS:132335-44-5

Ukwenziwa kanye nokufundwa kwe-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine kuthole isithakazelo emikhakheni yocwaningo lwezemithi kanye namakhemikhali. Ukwenziwa kwe-enantioselective kwale nhlanganisela kuyinselele kodwa kubalulekile ukufinyelela ama-enantiomer ahlanzekile okutadisha imisebenzi yawo yezemithi. Abacwaningi bathuthukise izindlela ezahlukene zokwenziwa besebenzisa ama-chiral resolving agents noma ama-catalyst angenawo u-asymmetric ukuthola i-enantiomer oyifunayo. Izifundo zibonise ukuthi i-(S)-enantiomer yama-beta-blockers afana ne-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine ingabonisa ukusondelana okuphezulu nokukhetha kuma-receptor e-beta-adrenergic uma kuqhathaniswa ne-(R)-enantiomer, okwenza kube yinto ethembisayo yokuthuthukiswa kwemithi okuqhubekayo. Ucwaningo olwengeziwe ngezakhiwo zezemithi kanye nekhono lokwelapha le-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine luyadingeka ukuhlola ukusebenza kwayo kanye nephrofayili yokuphepha ezindaweni zezokwelapha. Ukuqonda ubudlelwano besakhiwo nomsebenzi walesi sakhi kanye nokusebenzisana kwaso nama-beta receptors kungaholela ekuthuthukisweni kwama-beta-blockers amasha anemiphumela yokwelapha ethuthukisiwe kanye nemiphumela emibi encishisiwe. Sekukonke, i-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine imele into ebalulekile yamakhemikhali emkhakheni wocwaningo lwemithi, enikeza ukuqonda ngokwakhiwa kanye nokuthuthukiswa kwemithi yenhliziyo enezakhiwo zemithi ezithuthukisiwe.