(R)-tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate CAS:955406-14-1

(R)-tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate idlala indima ebalulekile njengomxhumanisi ekwakhiweni kwamakhemikhali ayinkimbinkimbi, asebenzayo kanye nezicelo ezingaba khona zemithi. Uhlobo lwayo lwe-chiral kanye nezici zayo ezihlukile zesakhiwo ziyibeka njengengxenye ebalulekile ekudalweni kwamakhemikhali e-enantiopure, abalulekile ekuthuthukisweni kwemithi. Ngokufaka lesi sakhiwo esakhiweni ezinhlakeni zama-molecule, abacwaningi bangahlola amakhemikhali amasha ahlose izindawo zokwelapha njengezinkinga zesistimu yezinzwa ephakathi, izifo ezithathelwanayo, noma i-oncology. Kumakhemikhali wezokwelapha, lesi sakhi singasebenza njengendawo yokuqala yokuklama amakhemikhali angaba khona, sisebenzisa i-stereochemistry yaso ukuze silawule umsebenzi wezinto eziphilayo kanye nezakhiwo ze-pharmacokinetic. Iqembu le-tert-butyl linikeza isithiyo se-steric futhi lithonya ukusebenzisana kwesakhi nezinhloso zezinto eziphilayo, okufaka isandla ekuhlolweni kwezindlela zokwelapha ezintsha. Ngaphezu kwalokho, ezindaweni zezemfundo nezezimboni, abacwaningi bangasebenzisa lesi sakhi ukulungiselela imitapo yolwazi yezinto ezahlukahlukene ezitholakala ezifundweni zobudlelwano besakhiwo nomsebenzi, okwenza kube lula ukuhlonza amakhemikhali e-lead anemiphumela efiselekayo yezinto eziphilayo. Indima yayo ekuhlanganisweni kwamakhemikhali ifinyelela ekukhiqizweni kwezidakamizwa ezihlanganisa imithi kanye nokuthuthukiswa kwezindlela ezintsha zokwenziwa, okubonisa ukusetshenziswa kwayo okubanzi kuzo zonke izigaba zesayensi. Sekukonke, i-(R)-tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate idlala indima ebalulekile ekuphishekeleni ukutholakala kwemithi emisha kanye nokuhlanganiswa okungalingani, okuhlinzeka ngeplatifomu yokuthuthukiswa kwama-molecule ahlukahlukene asebenzayo ngokwezinto eziphilayo kanye nezidakamizwa ezihlanganisa imithi.