I-Nitrocefin CAS:41906-86-9

Ema-laboratory e-microbiology emitholampilo, i-nitrocefin isetshenziselwa ukuhlola izakhi zamagciwane ukuze kukhiqizwe ama-enzyme e-beta-lactamase, anikeza ukumelana nama-antibiotic e-beta-lactam. Ukuhlolwa kuhilela ukufaka i-nitrocefin esikhumbeni samagciwane noma ngqo ekoloni lamagciwane kuma-agar plates. Uma amabhaktheriya ekhiqiza i-beta-lactamase, i-hydrolysis ye-nitrocefin iholela ekushintsheni kombala kusuka kophuzi kuya kobomvu ngemizuzu embalwa, okubonisa ukuba khona kwe-enzyme. Ukuhlolwa kwe-nitrocefin kuwusizo kakhulu ekuhlukaniseni phakathi kwezinhlobo zamabhaktheriya ezikhiqiza i-beta-lactamase nezingakhiqizi, okusiza ekukhetheni ukwelashwa okufanele kwama-antibiotic. Imiphumela emihle ikhombisa ukuthi amabhaktheriya amelana nama-antibiotic e-beta-lactam, okubangela ukusetshenziswa kwezinye izidakamizwa zokulwa namagciwane. Ngakolunye uhlangothi, imiphumela emibi iphakamisa ukuthambekela kuma-antibiotic e-beta-lactam, iqondisa odokotela ekukhetheni izinketho zokwelapha ezisebenzayo. Ngenxa yobulula nokushesha kwayo, ukuhlolwa kwe-nitrocefin kuvame ukusetshenziswa ema-laboratory emitholampilo ukuze kuhlolwe njalo ukuthambekela kwama-antimicrobial kanye nezinhloso zokulawula ukutheleleka. Kuhlinzeka ngolwazi olubalulekile kubahlinzeki bezempilo ukuze kuthuthukiswe ukwelashwa kwama-antibiotic kanye nokuvimbela ukusabalala kwama-bacteria amelana nama-antibiotic ezindaweni zokunakekelwa kwempilo. Izinyathelo zokulawula ikhwalithi ezifanele kanye neziqondiso zokuhumusha zibalulekile ukuqinisekisa ukunemba nokuthembeka kwemiphumela yokuhlolwa kwe-nitrocefin, okufaka isandla ekuphathweni kweziguli okuphumelelayo kanye nemizamo yokuphatha ama-antimicrobial.