I-Nitazoxanide CAS:55981-09-4

Ukusetshenziswa okuyinhloko kweNitazoxanide ekwelapheni izifo ezibangelwa yi-protozoa, njenge-Cryptosporidium parvum kanye ne-Giardia lamblia. Lezi zifo zivame ukuthinta indlela yokugaya ukudla futhi zingaholela ezimpawini ezifana nesifo sohudo, ubuhlungu besisu, kanye nesicanucanu. I-Nitazoxanide iphazamisa ukusebenza kahle kwamandla ezilokazane, okuholela ekufeni kwazo kanye nokuxazululwa kokutheleleka. Ukusebenza kwayo kahle ngokumelene nalezi zilokazane kwenze kwaba ithuluzi elibalulekile ekuphatheni izifo ezilokazane, ikakhulukazi ezinganeni nasezindaweni ezinezinga eliphezulu lokusabalala. Ngaphezu komsebenzi wayo wokulwa nezilokazane, i-Nitazoxanide ikhombisa izakhiwo ezithembisayo zokulwa namagciwane. Ibonise imiphumela yokuvimbela ngokumelene namagciwane ahlukahlukene, okuhlanganisa umkhuhlane, i-hepatitis B kanye ne-C, i-norovirus, i-rotavirus, kanye negciwane lokuphefumula elihambisanayo. Ucwaningo mayelana nokusetshenziswa kwayo okungenzeka ekwelapheni i-COVID-19 luthole ukunakwa okukhulu, njengoba kuqhubeka izivivinyo zemitholampilo zokuhlola ukusebenza kwayo ekunciphiseni ukuphindaphindeka kwegciwane kanye nokuguqula impendulo yomzimba ezigulini ezinezifo ze-coronavirus. Ngaphezu kwalokho, ukuphepha nokubekezeleleka kweNitazoxanide kuyenza ibe yinto ebalulekile yokwelapha okuhlanganisiwe kanye nokungenelela kokuvimbela ukuqubuka kwamagciwane kanye nobhubhane. Imisebenzi yayo eminingi yokulwa nezimuncagazi kanye ne-antiviral iyibeka njenge-ejenti eguquguqukayo emizamweni yomhlaba wonke yokulwa nezifo ezithathelwanayo, inikeza izinzuzo ezingaba khona kokubili ekwelashweni nasekuvimbeleni. Sekukonke, izakhiwo ezimbili zeNitazoxanide zokulwa nezimuncagazi kanye ne-antiviral zigcizelela ukubaluleka kwayo njenge-ejenti yemithi eguquguqukayo enemiphumela ebalulekile empilweni yomphakathi kanye nokuphathwa kwezifo.