I-Neocuproine reagent iyi-reagent yokunquma ithusi, ikristalu elimhlophe noma eliphuzi-nsundu, elicasulayo. Isetshenziswa kakhulu njenge-reagent yokunquma i-cuprous, photometric determination yethusi, ukunquma ushukela wegazi ophansi kakhulu; ukwakheka kwezinto eziphilayo. I-Neocuproine hydrochloride monohydrate isetshenziswe ekulinganiseni ukuncibilika kwethusi kuma-Cu-Ni alloys kusetshenziswa indlela ye-colorimetric. Isetshenziswe futhi ekulungiseleleni isisombululo se-complexing agent ekutadisheni ukuhlolwa kwamandla e-antioxidant kumasampula ebhayoloji asekelwe kuma-Cu reducing complexes. Ingasetshenziswa njengesandulela sokulungiselela i-neocuproine, isetshenziswe njenge-reagent yokuhlaziya yokunquma ithusi kumasampula emvelo kusetshenziswa indlela ye-spectrophotometric.
Kodwa-ke umuthi onjalo unokusetshenziswa okuhlukile kakhulu kwezokwelapha. Muva nje, i-Eribulin ivunyelwe ukumaketha yi-National Medical Products Administration (NMPA) yezwe lami ekwelapheni iziguli ezinomdlavuza webele ophindaphindayo noma osakazekile eziye zathola okungenani izindlela ezimbili zokwelashwa ngamakhemikhali (kufaka phakathi i-anthracyclines kanye ne-taxans) esikhathini esidlule. Ilethe iphethini entsha yokwelapha emkhakheni we-chemotherapy yomdlavuza webele eShayina, futhi iletha nezinketho eziningi zokwelashwa kweziguli.
I-Eribulin iyisivimbeli se-tubulin esingeyona i-taxane. Ngokungafani ne-taxane kanye ne-vinblastine tubulin inhibitors, i-Eribulin inendlela ekhethekile yokusebenza, okwenza i-Eribulin isasebenza ezigulini ngemuva kokumelana nemithi ye-yew; I-Eribulin futhi inemiphumela engeyona i-cytotoxic, okuhlanganisa nokuvuselela imithambo yegazi, ukwandisa ukugeleza kweminye imithi endaweni encane yesimila, ukuhlanganisa eminye imithi, kanye nokuguqula amaseli esimila Ukuguquka kwe-epidermal-mesenchymal nokunye.
Kusukela ekuhlanganisweni okuphelele kwe-halichondrin B, ukusetshenziswa kwama-reagent amasha ethusi njengezinto ezihlanganisayo, kuya ekuguqulweni kwesakhiwo se-Eribulin, kuya ekukhiqizweni kwezimboni kwe-Eribulin, ososayensi abavela ezinkampanini zemfundo ephakeme kanye nezinkampani zemithi bachithe iminyaka engaphezu kwengu-20 behlola. Imikhiqizo yemvelo etholakala olwandle isibe yimithi engelapha umdlavuza. Ucwaningo kanye nentuthuko ye-Eribulin kungenxa yokuthi i-reagent entsha yethusi ibalulekile njenge-intermediate eyinhloko ye-API yayo. I-reagent entsha yethusi inendima enkulu njenge-intermediate yemithi kanye ne-reagent yokuhlanza amathuluzi aphezulu.
Isakhiwo sama-molecule e-Eribulin siqukethe izikhungo ze-chiral ezingu-19, kanti izinyathelo zokwenziwa zingaba yizinyathelo ezingu-62. Kuze kube manje, i-Eribulin isabhekwa embonini njengomuthi oyinkimbinkimbi kakhulu ongeyona i-peptide okhiqizwa ukwenziwa kwamakhemikhali ahlanzekile, futhi ingabizwa ngokuthi i-Mount Everest embonini yokwenziwa kwamakhemikhali.
Ukufakwa ohlwini okuphumelelayo kwe-Eribulin kukhombisa ukuphakama okusha izinkampani zemithi ezingakufinyelela ekuhlanganisweni kwamakhemikhali kanye nokukhiqizwa kwezimboni. Kuphinde kulethe imibono eminingi yokuxilonga kanye nokwelashwa kanye nezinketho kodokotela baseShayina. Kuthenjwa ukuthi emtholampilo wesikhathi esizayo, umuthi omusha we-chemotherapeutic i-Eribulin ungaletha ithemba elisha ezigulini zomdlavuza webele.
Isikhathi sokuthunyelwe: Jan-01-2021