I-Neocuproine reagent i-reagent yokunquma ithusi, i-crystal emhlophe noma ephuzi-brown, ecasulayo.Ikakhulu isetshenziswa njenge-reagent yokunqunywa kwe-cuprous, ukunqunywa kwe-photometric yethusi, ukuzimisela kwe-ultra-micro blood sugar;i-organic synthesis.I-Neocuproine hydrochloride monohydrate isetshenziswe ekulinganiseni ukuncibilika kwethusi kuma-alloys e-Cu–Ni kusetshenziswa indlela ye-colorimetric.Iphinde yasetshenziswa ekulungiseleleni isisombululo se-ejenti eyinkimbinkimbi ekutadisheni ukuhlolwa kwamandla okulwa ne-antioxidant kumasampula ebhayoloji asuselwa ku-Cu reduction complexes.Ingase isetshenziswe njengesandulela sokulungiswa kwe-neocuproine, esetshenziswa njenge-reagent yokuhlaziya ukuze kutholakale ithusi kumasampuli emvelo kusetshenziswa inqubo ye-spectrophotometric.
Nokho nje umuthi onjalo unokusetshenziswa okuhluke kakhulu kwezokwelapha. Muva nje, i-Eribulin igunyazwe ukumakethwa yi-National Medical Products Administration (NMPA) yezwe lami ukuze zelashwe iziguli zomdlavuza webele eziphindelelayo noma ezithole i-metastatic ezithole okungenani ukwelashwa ngamakhemikhali okubili. izinhlobo zemithi (okuhlanganisa i-anthracyclines kanye nama-tax) esikhathini esidlule.Ilethe iphethini entsha yokwelashwa emkhakheni we-chemotherapy yomdlavuza webele e-China, Iphinde ilethe izindlela eziningi zokwelapha iziguli.
I-Eribulin iyi-non-taxane tubulin inhibitor.Ngokungafani ne-taxane kanye ne-vinblastine tubulin inhibitors, i-Eribulin inendlela ekhethekile yokwenza, okwenza i-Eribulin Isasebenza ezigulini ngemuva kokumelana nezidakamizwa ku-yew;I-Eribulin nayo inemiphumela engeyona i-cytotoxic, okuhlanganisa ukuguqulwa kwe-vascular, ukwandisa ukuchithwa kwezinye izidakamizwa ku-tumor microenvironment, ukuvumelanisa ezinye izidakamizwa, nokubuyisela emuva amaseli e-tumor Ukuguqulwa kwe-epidermal-mesenchymal nokunye.
Kusukela ekuhlanganiseni okuphelele kwe-halichondrin B, ukusetshenziswa kwama-reagents ethusi amasha njengabaphakathi, ukuguqulwa kwesakhiwo se-Eribulin, ukukhiqizwa kwezimboni ze-Eribulin, ososayensi abavela ezinkampanini zemfundo kanye nezinkampani zemithi baye bachitha iminyaka engaphezu kwe-20 yokuhlola.Imikhiqizo yemvelo etholakala olwandle isiphenduke izidakamizwa ezikwazi ukwelapha umdlavuza.Ucwaningo nokuthuthukiswa kwe-Eribulin yingoba i-reagent entsha yethusi ibalulekile njengendawo emaphakathi ye-API yayo.I-reagent entsha yethusi inendima enkulu njengendawo emaphakathi yemithi kanye ne-reagent yokuhlanza amathuluzi asezingeni eliphezulu.
Isakhiwo samangqamuzana e-Eribulin siqukethe izikhungo ze-chiral eziyi-19, futhi izinyathelo zokuhlanganisa zinde njengezinyathelo ezingama-62.Kuze kube manje, i-Eribulin isabhekwa yimboni njengesidakamizwa esiyinkimbinkimbi kunazo zonke esingeyona i-peptide ekhiqizwa ukuhlanganiswa kwamakhemikhali ahlanzekile, futhi ingabizwa ngokuthi i-Mount Everest embonini yokuhlanganisa amakhemikhali.
Ukufakwa kuhlu okuyimpumelelo kwe-Eribulin kukhombisa ukuphakama okusha okungafinyelelwa yizinkampani ezenza imithi ekuhlanganiseni amakhemikhali nokukhiqizwa kwezimboni.Futhi iletha imibono eminingi yokuxilongwa kanye nokwelashwa kanye nezinketho kubahlengikazi baseShayina.Kwethenjwa ukuthi ekusebenzeni komtholampilo kwesikhathi esizayo, umuthi omusha we-chemotherapeutic i-Eribulin ungaletha ithemba elisha ezigulini ezinomdlavuza webele.
Isikhathi sokuthumela: Jan-01-2021