I-N-Acetyl-L-phenylalanine ethyl ester CAS:2361-96-8

I-N-Acetyl-L-phenylalanine ethyl ester isetshenziswa kakhulu kumakhemikhali e-peptide kanye nomklamo we-prodrug, isebenza njengendawo ebalulekile yokwenziwa kwama-peptide kanye nama-amino acid derivatives aguquliwe. Osokhemisi nabacwaningi basebenzisa le nhlanganisela ukwethula izinguquko ezithile noma ukuhlukahluka kwesakhiwo ku-peptide sequences, okuvumela ukuthuthukiswa kwamakhemikhali amasha asebenzayo kanye nama-pharmaceutical agents anezakhiwo ezithuthukisiwe ze-pharmacokinetic kanye nezici zokulethwa eziqondiwe. Ngaphezu kwalokho, i-N-Acetyl-L-phenylalanine ethyl ester isetshenziswa ekuthuthukisweni kwama-prodrugs, lapho isakhiwo sayo samakhemikhali kanye nokuqina kunegalelo ekuhlanganisweni kwama-therapeutic agents angaba khona. Ngokufaka ingxenye ye-ethyl ester, yenza kube lula ukwakheka kwama-prodrugs ane-lipophilicity ethuthukisiwe kanye nokuvuleka kwe-membrane, okuthuthukisa ukutholakala kwawo kwe-bioavailability kanye nokuqina kwe-metabolic ekulethweni kwemithi okuqondiwe kanye nezicelo zokukhululwa ezilawulwayo. Ngaphezu kwalokho, i-N-Acetyl-L-phenylalanine ethyl ester isetshenziswa ocwaningweni lwemithi ukuphenya ubudlelwano besakhiwo nomsebenzi, ukuthuthukisa abantu abasha abazongenela izidakamizwa, kanye nokuhlola amasu e-prodrug okuthuthukisa iphrofayili yokwelapha yemithi esekelwe ku-phenylalanine. Indima yayo ekwakhiweni nasekuthuthukiseni izidakamizwa ezisetshenziswa ekwelapheni inegalelo ekuthuthukiseni ukutholakala kwezidakamizwa kanye nokuthuthukiswa kwemithi, inikeza ukuqonda okubalulekile ekuthuthukiseni ukusebenza kahle kanye nokuphepha kwezidakamizwa zokwelapha ezingaba khona. Ngamafuphi, i-N-Acetyl-L-phenylalanine ethyl ester idlala indima ebalulekile ekuthuthukiseni ucwaningo lwesayensi, ukwakheka kwe-peptide, ukuthuthukiswa kwezidakamizwa ezisetshenziswa ekwelapheni, kanye nezifundo zemithi, inikeza ososayensi nochwepheshe ithuluzi elisebenziseka ngezindlela eziningi lokuhlola ukusetshenziswa okuhlukahlukene kwezidakamizwa ezisetshenziswa ekwelapheni izidakamizwa, ukwakheka kwezidakamizwa ezisetshenziswa ekwelapheni.