I-L-Valine, i-3-methyl-N-(trifluoroacetyl)- (9CI) I-CAS:666832-71-9

Kumakhemikhali e-organic, i-L-Valine, i-3-methyl-N-(trifluoroacetyl)- (9CI) isebenza njengesakhiwo esiguquguqukayo sokuhlanganiswa kwamaketanga e-peptide ane-motifs ethile equkethe i-valine. Iqembu layo lokuvikela i-trifluoroacetyl lenza kube lula ukwakheka nokuguqulwa kwesibopho se-peptide esikhethiwe, okuvumela ukwakheka okwenziwe ngokwezifiso kwama-peptide analogs, ama-peptide conjugates, kanye nama-peptidomimetics. Abacwaningi basebenzisa leli khemikhali ukuhlola ubudlelwano besakhiwo nomsebenzi wama-peptide, ukuklama izindlela zokwelapha ezisekelwe kuma-peptide, nokuthuthukisa ukulandelana kwe-peptide okusha okunezakhiwo ze-biological ezithuthukisiwe. Leli khemikhali lithola ukusetshenziswa ekuhlanganisweni kwe-peptide kanye nokutholwa kwemithi, lapho lidlala indima ebalulekile ekudaleni ama-molecule e-peptide anemisebenzi eyahlukahlukene ye-pharmacological kanye nokusebenzisana okuqondiwe. I-L-Valine, i-3-methyl-N-(trifluoroacetyl)- (9CI) ivumela ukufakwa kwezinsalela ze-valine ezakhiweni ze-peptide ukuze kuthuthukiswe ukuzinza kwazo, ukutholakala kwezinto eziphilayo, kanye nokubopha ubudlelwano nama-receptor e-biological. Ukusetshenziswa kwayo ekuguqulweni nasekusebenzeni kwe-peptide kunegalelo ekuthuthukisweni kwemithi ye-peptide, izithibi ze-enzyme, kanye nama-diagnostic agents anezicelo ezingaba khona ku-biotechnology, kwezemithi, kanye nocwaningo lwezokwelapha. Ngaphakathi kwemboni yezemithi, i-L-Valine, i-3-methyl-N-(trifluoroacetyl)- (9CI) isetshenziselwa ukuhlanganiswa kwama-peptide aqukethe i-valine, ama-peptidic prodrugs, kanye nama-nanoparticles asekelwe ku-peptide ukuze kunikezwe imithi. Indima yayo kumakhemikhali we-peptide kanye nobunjiniyela be-peptide ivumela ukwakhiwa kwama-scaffolds amasha e-peptide anezakhiwo zokwelapha ezithuthukisiwe kanye nokuncipha kwe-immunogenicity. Ngokusebenzisa izici ezihlukile zale nhlanganisela, ososayensi bangahlola izindlela ezintsha ekuthuthukisweni kwemithi esekelwe ku-peptide, imithi eyenzelwe wena, kanye nokwelashwa okuqondiswe ezifweni ezahlukahlukene, okuhlanganisa umdlavuza, izifo ezithelelanayo, kanye nezinkinga ze-metabolic.