I-Glucose-6-Phosphate Dehydrogenase CAS:9001-40-5

I-Glucose-6-phosphate dehydrogenase (G6PD) iyi-enzyme ehilelekile endleleni yokuguqulwa kwe-glucose. Idlala indima ebalulekile ekukhiqizweni kwe-NADPH, i-molecule ebalulekile ezinqubweni ezahlukahlukene zamaseli, okuhlanganisa ukuvikela ama-antioxidant kanye nokuhlanganiswa kwama-fatty acids kanye ne-cholesterol.

I-G6PD ikhuthaza ukuguqulwa kwe-glucose-6-phosphate ibe yi-6-phosphogluconolactone, kuyilapho ngesikhathi esifanayo inciphisa i-NADP+ ibe yi-NADPH. Lokhu kusabela kubalulekile ekugcineni ukutholakala okwanele kwe-NADPH emaseli, okudingekayo ukuze kulinganiswe i-redox yamaseli kanye nokuvikelwa ekulimaleni kwe-oxidative.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

Ukuguqulwa Kweseli: I-G6PD ihilelekile endleleni yokuguqulwa kweglucose, ikakhulukazi indlela ye-pentose phosphate. Ikhuthaza ukuguqulwa kwe-glucose-6-phosphate ibe yi-6-phosphogluconolactone, okukhiqiza i-NADPH kule nqubo. I-NADPH iyi-molecule ebalulekile yezinqubo ezahlukahlukene zamaseli, okuhlanganisa ukuzivikela kwe-antioxidant, ukwenziwa kwe-biosynthesis yama-fatty acids kanye ne-cholesterol, kanye nokugcina ibhalansi ye-redox yamaseli.

Ukuvikela Ama-Antioxidant: I-NADPH ekhiqizwa yi-G6PD ibalulekile ekukhiqizweni kwe-glutathione encishisiwe (GSH), i-molecule ebalulekile yama-antioxidant. I-GSH ivikela amaseli ekucindezelekeni kwe-oxidative ngokunciphisa ama-free radicals kanye nezinhlobo ze-reactive oxygen (ROS). Ukuntuleka kwe-G6PD kungalimaza ukutholakala kwe-NADPH futhi kunciphise ukusebenza kahle kokuvikela ama-antioxidant, okuholela ekwandeni kokuthambekela kokulimala kwama-oxidative.

I-Hemolytic Anemia: Ukuntuleka kwe-G6PD yikona ukuntuleka kwama-enzyme okuvame kakhulu emhlabeni jikelele. Kuthinta kakhulu abesilisa futhi kungaholela ku-hemolytic anemia, isimo esibonakala ngokubhujiswa kwamangqamuzana abomvu egazi. Izimbangela ezithile, njengokutheleleka, imithi ethile (isb., imithi yokulwa nomalaleveva, imithi ye-sulfa), kanye nokudla okuthile (isb., ubhontshisi be-fava), kungabangela i-hemolysis kubantu abanokuntuleka kwe-G6PD. Ukuntuleka kubangela ukungakwazi ukulawula ukucindezeleka kwe-oxidative okubangelwa yilezi zimbangela, okuholela ekuqhekekeni kwamangqamuzana abomvu egazi.

I-Pharmacy Yezokwelapha: Ukuhlolwa kwe-G6PD kubalulekile ku-pharmacology yezokwelapha ukuvimbela ukusabela okubi kwemithi. Eminye imithi, njengemithi ethile yokulwa nomalaleveva (isb., i-primaquine) kanye nama-antibiotic (isb., ama-sulfonamides), ingadala i-hemolysis kubantu abanokuntuleka kwe-G6PD. Ukuhlolwa kwangaphambilini kokuntuleka kwe-G6PD kusiza ekuboneni abantu abasengozini futhi kungaqondisa ukukhetha imithi noma ukusetshenziswa kwezinye izindlela zokwelapha ukuvimbela izigameko ezinzima ze-hemolytic.

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	I-NA
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe
Inombolo ye-CAS	9001-40-5
Ukupakisha	Encane futhi enkulu
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.