I-Gabapentin CAS: 60142-96-3 Umhlinzeki Womkhiqizi

I-Gabapentin iyi-Amino acid ehlobene ngokwesakhiwo ne-γ-Aminobutyric Acid (GABA), eyenzelwe ukuwela umgoqo wegazi lobuchopho. Isetshenziswa njenge-anticonvulsant. Iphinde inikezwe iziguli ezine-multiple sclerosis ukulawula i-dysesthesia futhi ingaba usizo ekunciphiseni ubuhlungu be-neuropathic obubangelwa umdlavuza kanye nokutheleleka yi-HIV. Ayibophi kuma-GABA receptors, ayithinti ukumuncwa kwe-GABA kwemizwa, futhi ayivimbeli i-GABA-metabolizing enzyme, i-GABA transaminase. Ngokungafani ne-GABA, engadluli emgoqo wegazi nobuchopho, i-gabapentin ingena ohlelweni lwezinzwa oluphakathi futhi ibopha eziteshini ze-calcium ezivikelwe yi-α2δ-type voltage-gated. Indlela yokusebenza yemiphumela ye-gabapentin yokunciphisa ubuhlungu kanye ne-anticonvulsant ayikaziwa.