I-Fmoc-Tyr(But)-OSu CAS:155892-27-6

I-Fmoc-Tyr(But)-OSu isebenza njenge-reagent ebalulekile ekwakhiweni kwe-peptide, ikakhulukazi ekuguqulweni okukhethiwe kwamaprotheni nama-peptide. Ukusebenza kwe-OSu ester kuvumela ukuhlanganiswa okuphumelelayo kwe-tyrosine kuma-molecule aqukethe ama-amine noma izisekelo eziqinile, okusiza ukwethulwa kwezinsalela ze-tyrosine ezindaweni ezithile ngaphakathi kochungechunge lwe-peptide. Iqembu le-Fmoc lingasuswa ngaphansi kwezimo ezithambile ukuze liveze i-OSu ester esabelayo, okuvumela ukusabela okulandelayo kokuhlanganiswa. Ngaphezu kwalokho, i-Fmoc-Tyr(But)-OSu ithola ukusetshenziswa okukhulu kumasu okuhlanganiswa kwe-bio okuthuthukisa ama-conjugates e-protein-drug, ama-probe okucabanga asekelwe ku-peptide, kanye nokwakhiwa kwemithi yokugoma. Ukuhambisana kwayo nokuhlanganiswa kwe-peptide yesigaba esiqinile kwenza kudalwe ama-conjugates e-peptide enziwe ngokwezifiso aklanyelwe izinhlelo zokusebenza ezahlukahlukene ze-biomedical, kufaka phakathi ukulethwa kwemithi okuqondiwe kanye namathuluzi okuxilonga. Ngamafuphi, i-Fmoc-Tyr(But)-OSu idlala indima ebalulekile ekuthuthukiseni ucwaningo lwe-bioconjugation kanye ne-peptide chemistry, inika amandla ososayensi nabacwaningi ukuthuthukisa ama-conjugates nama-peptide amasha anezinhlelo zokusebenza zokwelapha, zokuxilonga, kanye nocwaningo ezingaba khona.