I-Fmoc-Glu(But)-NH2 CAS:104090-92-8

I-Fmoc-Glu(But)-NH2 isebenza njengethuluzi eliguquguqukayo ekuhlanganisweni kwe-peptide, inikeza abacwaningi ikhono lokufaka i-glutamic acid ngokulawula okunembile kanye nokuguquguquka. Iqembu elivikela i-Fmoc livikela iqembu lama-amino, liqinisekisa ukusabela okukhethayo ngesikhathi sokuhlanganiswa kwe-peptide, kuyilapho iqembu le-butyl linezela ungqimba olwengeziwe lokuvikela eqenjini le-carboxyl. Abacwaningi basebenzisa kakhulu i-Fmoc-Glu(But)-NH2 ekwakhiweni kwama-peptide ngezinhlelo zokusebenza ezahlukahlukene, okuhlanganisa ukwakheka kwe-peptide mimetics, ukuhlanganiswa kwe-peptide, kanye nokuthuthukiswa kwama-peptide asebenzayo. Iqembu lama-amino livumela ukusebenza okwengeziwe, okuvumela ukunamathiswa kwama-molecule ahlukahlukene, ama-fluorophores, noma ezinye izinto ukuze kulungiswe izakhiwo zama-peptide ahlanganisiwe. Ngaphezu kwalokho, i-Fmoc-Glu(But)-NH2 ithola usizo ezifundweni ezihlobene nokuthuthukiswa kwemithi esekelwe kwi-peptide, njengoba iqembu lokuvikela i-butyl lithuthukisa ukuzinza nokukhululwa okulawulwayo kwe-glutamic acid efakiwe. Ukuhambisana kwayo nezindlela ezijwayelekile zokwenziwa kwe-peptide, kokubili kumasu esigaba esiqinile kanye nesigaba sesisombululo, kuthuthukisa ukuguquguquka kwayo emizamweni yocwaningo eyahlukahlukene. Ngamafuphi, i-Fmoc-Glu(But)-NH2 imele njengethuluzi eliyisisekelo nelibalulekile kumakhemikhali e-peptide, inikeza abacwaningi isakhiwo esiguquguqukayo sokwenziwa kwama-peptide aklanyelwe wona anemisebenzi ethile, ikakhulukazi egxile kuma-peptide aqukethe i-glutamic acid.