I-Fmoc-D-Gln-OH CAS:71989-20-3

I-Fmoc-D-Gln-OH isebenza njengethuluzi elikhethekile ekuhlanganisweni kwama-peptide, elenzelwe ngqo ukwakha ama-peptide aqukethe i-D-glutamine ngokunemba. Iqembu elivikela i-Fmoc livikela iqembu lama-amino, liqinisekisa ukusabela okukhethayo ngesikhathi sokuhlanganiswa kwama-peptide, kuyilapho ukufakwa kwe-D-enantiomer kunezela ubukhulu obuhlukile kuma-peptide ahlanganisiwe. Abacwaningi basebenzisa kakhulu i-Fmoc-D-Gln-OH ekwakhiweni kwama-peptide ngezinhlelo ezahlukahlukene, kufaka phakathi izifundo ezibandakanya ama-D-amino acid, ukwelashwa okusekelwe kuma-peptide, kanye nama-peptide asebenzayo anezimpawu ezithile zesakhiwo. Ukuhambisana kwayo nezindlela ezijwayelekile zokwenziwa kwama-peptide, kokubili kumasu esigaba esiqinile kanye nesigaba sesisombululo, kuthuthukisa ukuguquguquka kwayo emizamweni yocwaningo eyahlukahlukene. Ukususwa okulawulwayo kwamaqembu avikelayo kuvumela ukufakwa kwe-D-glutamine ngamasu okulandelana kwama-peptide, kwandisa amathuba okwenziwa kwama-peptide nge-stereochemistry eshintshiwe. Ngaphezu kwalokho, i-Fmoc-D-Gln-OH ithola usizo ezifundweni ezihlobene ne-peptidomimetics, lapho ukusetshenziswa kwama-D-amino acid kunganikeza ukuzinza okuthuthukisiwe kanye nomsebenzi oshintshiwe we-bioactivity kuma-peptide ahlanganisiwe. Ukusetshenziswa okunesu kwe-Fmoc-D-Gln-OH kwenza kube lula ukuphathwa kahle kwe-D-glutamine reactivity, okunikeza abacwaningi ithuluzi eliwusizo lokuklama ama-peptide anezici ezihlukile ze-stereochemical. Ngamafuphi, i-Fmoc-D-Gln-OH imele njengethuluzi elikhethekile nelibalulekile kumakhemikhali e-peptide, inika abacwaningi amandla okuhlola nokuguqula i-D-glutamine reactivity yezinhlelo zokusebenza ezithile zesayensi, ikakhulukazi ukugxila kuma-peptide aqukethe lolu hlobo lwe-enantiomeric lwe-amino acid ebalulekile.