I-Fmoc-Arg(pbf)-OH CAS:154445-77-9

I-Fmoc-Arg(pbf)-OH isebenza umsebenzi obalulekile ekwakhiweni kwe-peptide, ikakhulukazi ezimweni ezidinga ukuvikelwa okulawulwayo kwe-guanidine nitrogen ku-arginine. Iqembu elivikela i-Fmoc livikela iqembu lama-amino, lenze kube lula ukusabela okukhethayo ngesikhathi sokuhlanganiswa kwe-peptide, kuyilapho iqembu le-pbf ku-guanidine nitrogen linikeza ungqimba olwengeziwe lokuvikela. Abacwaningi basebenzisa i-Fmoc-Arg(pbf)-OH ekwakhiweni kwama-peptide ngokuguqulwa okuthile kwe-guanidine, okuthinta imisebenzi yabo yebhayoloji. Isu lokuvikela okubili livumela ukuphathwa okunembile kwe-reactivity ye-guanidine, okwenza leli khemikhali libe wusizo ekwakhiweni nasekuthuthukisweni kwama-peptide ezifundweni zokulwa namagciwane, i-bioconjugation, kanye ne-chemistry yezokwelapha. Ukuhambisana kwe-Fmoc-Arg(pbf)-OH nezindlela ezijwayelekile zokwenziwa kwe-peptide, kufaka phakathi i-solid-phase peptide synthesis (SPPS), kuthuthukisa ukusebenza kwayo. Le nhlanganisela ithola ukusetshenziswa ekwakhiweni kwama-peptide okuhlolwa kwezinto eziphilayo, ukutholakala kwemithi, kanye nokuthuthukiswa kwezinto ezisekelwe kuma-peptide. Ukususwa okulawulwayo kwamaqembu avikelayo kuvumela ukufakwa kwe-arginine nge-guanidine eguquliwe, okufaka isandla ekwahlukeni kwama-peptide angakhiwa. Ngamafuphi, i-Fmoc-Arg(pbf)-OH imele njengethuluzi elikhethekile neliguquguqukayo kumakhemikhali e-peptide, okunika amandla abacwaningi ukuthi bahlole futhi bashintshe ukusabela kwe-guanidine kwezinhlelo zokusebenza zesayensi nezokwelapha ezahlukahlukene.