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I-2-Hydroxyisonicotinic acid CAS:90-33-5
I-2-Hydroxyisonicotinic acid iyi-derivative ye-isonicotinic acid, ebonakala ngokuba khona kweqembu le-hydroxyl endaweni yesibili yendandatho ye-pyridine. Le nhlanganisela ibonisa imisebenzi ehlukahlukene yebhayoloji, okuhlanganisa izakhiwo ezingaba khona zokulwa namagciwane kanye nokulwa nokuvuvukala. Ukufana kwayo kwesakhiwo nezinye izinto ezitholakala ku-nicotinic acid kwenza kube yinto ethakazelisayo yokuthuthukiswa kwemithi. Abacwaningi bebehlola ukusetshenziswa kwayo kumakhemikhali ezokwelapha, ikakhulukazi ekwelapheni izifo ezahlukahlukene. Le nhlanganisela isebenza njengesisekelo sokwakha ama-molecule ayinkimbinkimbi kakhulu futhi idonsele ukunaka emikhakheni yokwenziwa kwezinto eziphilayo kanye nocwaningo lwemithi.
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I-Methyl 2-aminopyridine-4-carboxylate CAS:6937-03-7
I-Methyl 2-aminopyridine-4-carboxylate iyi-derivative ye-pyridine equkethe iqembu lama-amino endaweni engu-2 kanye ne-ester ye-carboxylate endaweni engu-4, eneqembu le-methyl elinamathiselwe ku-carboxylic acid. Le nhlanganisela inesithakazelo kumakhemikhali ezokwelapha ngenxa yemisebenzi yayo engaba khona yezinto eziphilayo, okuhlanganisa izakhiwo zokulwa namagciwane kanye nezokulwa nokuvuvukala. Ukuhlelwa okuhlukile kwamaqembu asebenzayo kuthuthukisa ukusabela kwayo kanye nokusetshenziswa kwayo njengesakhiwo esiguquguqukayo ekuhlanganisweni kwezinto eziphilayo. Ucwaningo luyaqhubeka nokuhlola ukusetshenziswa kwayo ekuthuthukisweni kwemithi nakwezinye izinkambu, okubonisa ukubaluleka kwayo ngaphakathi kwendawo ye-heterocyclic chemistry.
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I-Tofacitinib Citrate CAS:540737-29-9
I-Tofacitinib citrate iyi-Janus kinase (JAK) inhibitor yomlomo esetshenziswa ngokuyinhloko ekwelapheni i-rheumatoid arthritis, i-psoriatic arthritis, kanye ne-ulcerative colitis. Isebenza ngokuvimbela ngokukhetha ama-enzyme e-JAK1 kanye ne-JAK3, adlala indima ebalulekile ezindleleni zokubonisa izimpawu zama-cytokine ahlukahlukene ahilelekile ezinqubweni zokuvuvukala. Ngefomula yama-molecule C16H20N6O5S·C6H8O7, i-tofacitinib citrate ibonise ukusebenza kahle ekunciphiseni ukuvuvukala kanye nokuthuthukisa ikhwalithi yokuphila kwesiguli. Ivunyelwe ukusetshenziswa kwezokwelapha emazweni amaningana, ucwaningo oluqhubekayo luhlose ukuhlola izinhlelo zayo zokwelapha ezibanzi, iphrofayili yokuphepha, kanye nemiphumela yesikhathi eside ezifweni ezahlukahlukene zokuzivikela komzimba.
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I-Cyclen CAS:294-90-6
I-Cyclen, noma i-1,4,7,10-tetraazacyclododecane, iyinhlanganisela ye-polyamine ephawulekayo ngesakhiwo sayo esiyingqayizivele esijikelezayo esinama-athomu amane e-nitrogen afakwe endandatho enamalungu ayishumi nambili. Ngefomula yama-molecule i-C8H16N4, i-cyclen isebenza njenge-ligand ebalulekile kumakhemikhali okuxhumana ngenxa yekhono layo lokwakha ama-complexes azinzile ngezinsimbi zokuguquka. Izakhiwo zayo zokuchela ziyenza ibe yigugu ezisetshenzisweni ezahlukahlukene, kufaka phakathi ikhemistri yezokwelapha, i-radiopharmaceuticals, kanye nekhemistri ye-supramolecular. Ucwaningo oluqhubekayo luhlola amandla e-cyclen ezinhlelweni zokulethwa kwemithi kanye nokuthuthukiswa kwama-ejenti okuthwebula izithombe aqondiwe, kugcizelela ukubaluleka kwayo kokubili kwezesayensi eziyisisekelo nezisetshenziswayo.
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![I-4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane CAS:57280-22-5](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT317.png)
I-4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane CAS:57280-22-5
I-4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane iyinhlanganisela yezinto eziphilayo ezi-bicyclic ebonakala ngesakhiwo sayo esiyingqayizivele equkethe ukuxhumana okubili kwe-ether kanye nama-athomu amathathu e-oxygen ngaphakathi kohlaka lwe-bicyclic. Ngefomula yama-molecule i-C10H16O3, le nhlanganisela ikhombisa izakhiwo zamakhemikhali ezithakazelisayo ngenxa yokuba khona kwamaqembu e-methyl kanye nokusebenza kwe-ether. Ukwakheka kwayo kwe-bicyclic kunegalelo ekuzinzeni nasekusebenzeni kwayo, okwenza kube yinto engaba khona yezicelo ezahlukahlukene kumakhemikhali ezinto eziphilayo zokwenziwa. Ucwaningo luhlola ukusetshenziswa kwayo ekwakhiweni kwama-molecule ayinkimbinkimbi kakhulu kanye namandla ayo njengesisekelo sokwakha kwezesayensi yezokwelapha nezinto ezibonakalayo.
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![I-4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine CAS:479633-63-1](https://cdn.globalso.com/xindaobiotech/VMLV8UWXAZ0XBLS6M290.png)
I-4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine CAS:479633-63-1
I-4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine iyinhlanganisela yokwenziwa ephawulekayo ngokusetshenziswa kwayo okungaba khona kwezokwelapha. Inesakhiwo esiyingqayizivele esihlanganisa umongo we-pyrrolopyrimidine, indawo ye-chloro, kanye nengxenye ye-sulfonyl exhunywe eqenjini le-para-methylphenyl. Lokhu kwakheka kwesakhiwo kungafaka isandla emsebenzini wayo wezinto eziphilayo, okwenza kube yinto efanelekile yokucwaninga ezindaweni ezifana ne-oncology noma ukuvuvukala. Izifundo ziyaqhubeka ukuhlola izindlela zayo zokusebenza, ukusebenza kahle, kanye nephrofayili yokuphepha, ngenhloso yokuhlonza ukusetshenziswa kwayo okungenzeka kwezokwelapha ezimweni ezahlukene zezokwelapha.
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I-3-Pyridinesulfonyl chloride CAS:16133-25-8
I-3-Pyridinesulfonyl chloride iyinhlanganisela ebalulekile yezinto eziphilayo enefomula yama-molecule i-C6H6ClN O2S. Iyi-sulfonyl chloride derivative ye-pyridine, equkethe iqembu elisebenzayo le-sulfonyl chloride elinamathiselwe endaweni yesithathu yendandatho ye-pyridine. Le nhlanganisela isetshenziswa kakhulu ekwakhiweni kwezinto eziphilayo njenge-reagent yokwethulwa kwamaqembu e-sulfonyl kuma-substrate ahlukahlukene. Ukusabela kwayo kuyivumela ukuthi ihlanganyele ekuphenduleni kokushintshana kwe-nucleophilic, okwenza ibe wusizo ekwakhiweni kwe-sulfonamides namanye ama-molecule asebenzayo. Ngaphezu kwalokho, i-3-pyridinesulfonyl chloride inokusetshenziswa okungenzeka kwezokwelapha kanye namakhemikhali ezolimo.
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I-2-Aminoisonicotinic acid CAS:13362-28-2
I-2-Aminoisonicotinic acid iyi-derivative ye-pyridine, ikakhulukazi i-isomer ye-nicotinic acid, ebonakala ngokuba khona kweqembu lama-amino endaweni engu-2 yesakhiwo se-isonicotinic acid. Ngefomula yama-molecule i-C6H6N2O2, le nhlanganisela ikhombisa izakhiwo zamakhemikhali ezithakazelisayo futhi ithole ukunakwa kumakhemikhali ezokwelapha ngenxa yemisebenzi yayo engaba khona yezinto eziphilayo, okuhlanganisa nemiphumela yokulwa namagciwane kanye nokulwa nokuvuvukala. Ukusebenza kwe-amino ne-carboxylic acid kuvumela ukuguqulwa kwamakhemikhali ahlukahlukene, okwenza kube yindawo ebalulekile yokwenziwa kwezinto eziphilayo. Ucwaningo oluqhubekayo luhlola amandla ayo okwelapha, luqokomisa ukubaluleka kwayo ekuthuthukisweni kwemithi nakwezinye izinhlelo zokusebenza.
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I-2-Amino-4-cyanopyridine CAS:42182-27-4
I-2-Amino-4-cyanopyridine iyi-derivative ye-pyridine ebonakala ngeqembu lama-amino endaweni engu-2 kanye neqembu le-cyano endaweni engu-4 yendandatho ye-pyridine. Ngefomula yama-molecule i-C6H4N4, le nhlanganisela ikhombisa izakhiwo zamakhemikhali ezithakazelisayo kanye nemisebenzi engaba khona yezinto eziphilayo. Ihlolisiswe ukusetshenziswa kwayo kumakhemikhali ezokwelapha, ikakhulukazi ekuthuthukisweni kwemithi ngenxa yemiphumela yayo engaba khona yokulwa namagciwane, i-antifungal, kanye ne-anti-inflammatory. Ukuba khona kwamaqembu womabili asebenzayo kuthuthukisa ukusabela kwayo, okwenza kube yindawo ebalulekile yokwenziwa kwezinto eziphilayo. Ucwaningo luyaqhubeka nokuhlola ukuguquguquka kwayo emikhakheni ehlukahlukene kufaka phakathi imithi kanye namakhemikhali ezolimo.
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2-(4-Hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid, i-ethyl ester, i-hydrochloride (1:1) I-CAS:399017-10-8
I-2-(4-Hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid, i-ethyl ester, i-hydrochloride (1:1) iyi-derivative ye-thiazole, ebonakala ngesakhiwo sayo esiyingqayizivele esihlanganisa iqembu le-hydroxyl, iqembu le-methyl, kanye ne-ethyl ester. Le khompawundi ithole isithakazelo kumakhemikhali ezokwelapha ngenxa yemisebenzi yayo engaba khona yezinto eziphilayo, njengezakhiwo zokulwa nokuvuvukala kanye nezokulwa namagciwane. Uhlobo lukasawoti we-hydrochloride luthuthukisa ukuncibilika kanye nokuqina, okwenza kube lula ukusetshenziswa kwalo ekwakhiweni kwemithi. Ucwaningo luyaqhubeka nokuphenya ukusebenza kwalo ezinhlelweni ezahlukene zokwelapha, okwenza kube yinto ebalulekile yezifundo ezengeziwe ekuthuthukisweni kwemithi kanye nokwenza ngcono i-lead.
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I-3-Methyl-4-nitropyridine N-Oxide CAS:1074-98-2
I-3-Methyl-4-nitropyridine I-N-oxide iyi-derivative ye-pyridine ebonakala ngeqembu le-methyl endaweni engu-3 kanye neqembu le-nitro endaweni engu-4 yendandatho ye-pyridine, kanye neqembu elisebenzayo le-N-oxide. Le nhlanganisela ibonisa izakhiwo zamakhemikhali eziphawulekayo kanye nemisebenzi yezinto eziphilayo, okwenza ibe nesithakazelo emikhakheni ehlukahlukene njenge-chemistry yezokwelapha kanye namakhemikhali ezolimo. Ukuba khona kwamaqembu e-nitro kanye ne-N-oxide kungathuthukisa ukusabela kwayo kanye nezicelo ezingaba khona kumakhemikhali okwenziwa. Ucwaningo luyaqhubeka nokuhlola ukusetshenziswa kwale nhlanganisela ekutholakaleni kwezidakamizwa nakwezinye izinhlelo zokusebenza, okubonisa ukubaluleka kwayo kumakhemikhali e-organic anamuhla.
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(1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine I-CAS:511534-44-4
(1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine iyinhlanganisela ebalulekile ye-chiral equkethe iqembu elisebenzayo le-sulfonamide kanye nomgogodla we-diphenylethylene. Ngefomula yama-molecule C16H20N2O2S, le nhlanganisela idlala indima ebalulekile ekuhlanganisweni nasekuxazululweni kwe-asymmetric ngenxa yamandla ayo okwakha izindawo ezizinzile ze-chiral. Isakhiwo sayo esiyingqayizivele sivumela ukusabela okukhethiwe, okwenza ibe usizo ekuthuthukisweni kwemithi kanye namakhemikhali ezolimo. Ucwaningo oluqhubekayo luhlola ukusetshenziswa kwayo ekuhlanganisweni kwe-stereoselective, luqokomisa amandla ayo njenge-ligand kumakhemikhali e-organometallic futhi lwandisa ukufaneleka kwayo ekuhlanganisweni kwe-organic yesimanje.
