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1 '1-Bis(diphenylphosphino)ferrocene I-Palladium(Ⅱ)chloride i-dichloromethane chloride i-CAS:95464-05-4
I-1,1-Bis(diphenylphosphino)ferrocene I-Palladium(II) Chloride I-Dichloromethane Complex, enefomula yamakhemikhali [Pd(dppf)Cl₂·CH₂Cl₂], iyinhlanganisela ye-organometallic equkethe i-palladium(II) ehlanganiswe ne-dppf ligand nama-chloride ku-solvent ye-dichloromethane. Ivame ukusetshenziswa ekuhlanganiseni nasekulungiseni i-organic.
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I-N-(6-bromopyridin-2-yl)thiourea CAS:439578-83-3
I-N-(6-Bromopyridin-2-yl)thiourea iyinhlanganisela yamakhemikhali ebonakala ngokuba khona kweqembu elisebenzayo le-thiourea elixhunywe engxenyeni ye-6-bromopyridin-2-yl. Le nhlanganisela ithole isithakazelo kumakhemikhali ezokwelapha ngenxa yemisebenzi yayo eyahlukahlukene yezokwelapha kanye nezinhlelo zokwelapha ezingaba khona. Izici zayo ezihlukile zesakhiwo zinikeza izindlela zokuklama izinhlobo ezintsha zemithi enezinhloso ezithile zebhayoloji, okwenza kube yimpahla ebalulekile ekutholakaleni nasekuthuthukisweni kwemithi.
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2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL CAS:269409-97-4
I-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, eyaziwa kakhulu ngokuthi i-TMDBP, iyinhlanganisela yamakhemikhali eyingxenye yesigaba sama-ester e-phenolic boronic. Isakhiwo sayo sama-molecule sakha iqembu le-phenolic hydroxyl elixhunywe endandatho ye-phenyl ephethe i-ester ejikelezayo equkethe i-boron. Le nhlanganisela ibalulekile ekwakhiweni kwezinto eziphilayo, ikakhulukazi ekuphenduleni kwe-Suzuki-Miyaura, lapho isebenza khona njenge-reagent ewusizo ye-boronic ester. Ngaphezu kwalokho, isakhiwo sayo se-boronate esizinzile esijikelezayo kanye nemvelo evinjiwe kahle kuyenza ibe usizo ekwakhiweni kwama-ligand okusabela kwe-transition metal-catalyzed kanye nasekuthuthukisweni kwezinto ezisebenzayo.
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I-1-Methyl-4-pyrazole boronic acid i-pinacol ester CAS:761446-44-0
I-1-Methyl-4-pyrazole boronic acid i-pinacol ester iyinhlanganisela yamakhemikhali ehlukaniswe njenge-boronic ester. Isakhiwo sayo sama-molecule siqukethe ingxenye ye-boronic acid enamathiselwe endandatho ye-pyrazole ethathelwe indawo yiqembu le-pinacol ester (-OC(CH₃)₂C(CH₃)₂O-). Le nhlanganisela ibaluleke kakhulu ekuhlanganisweni kwezinto eziphilayo, ikakhulukazi ekuphenduleni kwe-Suzuki-Miyaura cross-coupling, lapho isebenza khona njenge-reagent ye-boronic ester eguquguqukayo. Ngaphezu kwalokho, ukuzinza kwayo, ukusabela kwayo okukhethiwe, kanye nokuhambisana nezimo ezahlukahlukene zokusabela kuyenza ibe wusizo ekuhlanganisweni kwezinto ezisetshenziswayo zemithi, amakhemikhali ezolimo, kanye nezinto ezisebenzayo.
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![I-Cyclopenta[b]pyrrole-3a(1H)-methanol, i-hexahydro- CAS:1784081-72-6](https://cdn.globalso.com/xindaobiotech/1ZNB2ZF342ZWRNG285.png)
I-Cyclopenta[b]pyrrole-3a(1H)-methanol, i-hexahydro- CAS:1784081-72-6
I-Cyclopenta[b]pyrrole-3a(1H)-methanol, i-hexahydro- iyinhlanganisela ye-bicyclic ehlanganisiwe enesakhiwo se-cyclopenta[b]pyrrole core kanye ne-side chain ye-hexahydro-1H-pyrrole-3a(1H)-methanol. Le molekyuli ibalulekile kumakhemikhali ezokwelapha ngenxa yemisebenzi yayo engaba khona yezokwelapha. Isakhiwo sayo esiyingqayizivele sinikeza amathuba okuthuthukiswa kwezidakamizwa ezintsha, ikakhulukazi ezigxile ezinkingeni zemizwa nezinye izifo lapho ukuguqulwa kwama-receptor e-neurotransmitter kanye nabathuthi kubalulekile khona. I-Cyclopenta[b]pyrrole-3a(1H)-methanol, i-hexahydro- isebenza njengesikafu samakhemikhali ezokwelapha ahlola ama-ejenti amasha okwelapha anezakhiwo ze-pharmacokinetic ezithuthukisiwe kanye nemiphumela emibi encishisiwe.
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i-trans-1-(tert-Butoxycarbonyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylicacid CAS:169248-97-9
I-Trans-1-(tert-butoxycarbonyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid iyi-molecule eyinkimbinkimbi enendandatho ye-pyrrolidine ethathelwe indawo yiqembu le-tert-butoxycarbonyl endaweni yoku-1 kanye neqembu le-3-(trifluoromethyl)phenyl endaweni yoku-4. Le khompawundi ibalulekile kumakhemikhali ezokwelapha, ikakhulukazi ngenxa yamandla ayo njenge-pharmacophore ekwakhiweni kwemithi. Isakhiwo sayo esiyinkimbinkimbi sinikeza amathuba okudala ama-ejenti amasha okwelapha anezakhiwo ze-pharmacological ezenzelwe wena, ikakhulukazi ekuqondiseni izindlela ezithintekayo ezifweni zokuvuvukala, umdlavuza, noma ukuphazamiseka kwesistimu yezinzwa ephakathi.
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(3R,4S)-1-tert-Butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride CAS:1262849-90-0
(3R,4S)-1-tert-Butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride iyinhlanganisela yamakhemikhali ebonakala ngendandatho ye-pyrrolidine ethathelwe indawo yiqembu le-ethyl endaweni engu-3 kanye neqembu le-tert-butyl endaweni engu-1. Le nhlanganisela idonsele ukunaka kumakhemikhali wezokwelapha ngenxa yokuma kwayo kwe-stereochemical kanye nezicelo ezingaba khona zemithi. Ukuhleleka kwayo okuhlukile kunikeza izindlela zokuklama izinhlobo ezintsha zemithi ngezinhloso ezithile zezinto eziphilayo, okwenza kube yimpahla ebalulekile ekutholakaleni kwemithi kanye nemizamo yokuthuthukisa.
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I-Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride CAS:1233501-65-9
I-Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride iyinhlanganisela yamakhemikhali ehlukaniswa yindandatho ye-pyrrolidine ethathelwe indawo yiqembu le-ethyl endaweni engu-3 kanye neqembu le-tert-butyl endaweni engu-1. Le nhlanganisela idonsele ukunaka kumakhemikhali wezokwelapha ngenxa yobunzima bayo besakhiwo kanye nezinhlelo zokusebenza zemithi ezingaba khona. Ukuhleleka kwayo okuhlukile kunikeza amathuba okuklama izinhlobo ezintsha zemithi ngezinhloso ezithile zezinto eziphilayo, okwenza kube yimpahla ebalulekile ekutholakaleni kwemithi kanye nemizamo yokuthuthukisa.
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I-4-Hydroxyphenylboronic acid i-pinacol ester CAS:269409-70-3
I-4-Hydroxyphenylboronic acid pinacol ester, eyaziwa nangokuthi i-4-HPBA pinacol ester, iyinhlanganisela yamakhemikhali ewela ngaphansi kwesigaba sama-ester e-boronic. Isakhiwo sayo sama-molecule sakha ingxenye ye-boronic acid enamathiselwe endandatho ye-phenyl ethathelwe indawo yiqembu le-pinacol ester (-OC(CH₃)₂C(CH₃)₂O-). Le nhlanganisela ibaluleke kakhulu ekuhlanganisweni kwezinto eziphilayo, ikakhulukazi ekuphenduleni kwe-Suzuki-Miyaura cross-coupling, lapho isebenza khona njenge-reagent ye-boronic ester eguquguqukayo. Ngaphezu kwalokho, ukuzinza kwayo, ukulula kokuphathwa, kanye nokuhambisana nezimo ezahlukahlukene zokusabela kwenza kube wusizo ekuhlanganisweni kwezinto ezisetshenziswayo zemithi, imikhiqizo yemvelo, kanye nezinto ezisebenzayo.
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![I-Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride CAS:1057260-89-5](https://cdn.globalso.com/xindaobiotech/HSUS81DS80Y35NTEZTU259.png)
I-Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride CAS:1057260-89-5
I-Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride iyinhlanganisela yamakhemikhali equkethe iqembu elisebenzayo le-carbamate elixhunywe endandatho ye-piperidine elithathelwe indawo yiqembu le-benzyl ku-athomu ye-nitrogen kanye neqembu le-propyl ku-athomu ye-carbon. Le nhlanganisela ivuse isithakazelo kumakhemikhali ezokwelapha ngenxa yobunzima bayo besakhiwo kanye nezinhlelo zokusebenza zemithi ezingaba khona. Ilungiselelo layo eliyingqayizivele linikeza amathuba okuklama izinhlobo ezintsha zemithi ezinezinhloso ezithile zezinto eziphilayo, okwenza kube yimpahla ebalulekile ekutholakaleni kwemithi kanye nemizamo yokuthuthukiswa kwayo.
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I-9,9-Dimethyl-9H-fluoren-2-yl-boronic acid CAS:333432-28-3
I-9,9-Dimethyl-9H-fluoren-2-yl-boronic acid, evame ukubizwa ngokuthi i-DMFBA, iyinhlanganisela yamakhemikhali eyingxenye yesigaba sama-asidi e-boronic. Isakhiwo sayo sama-molecule sine-boronic acid ehlanganisiwe ne-scaffold ye-fluorene ethathelwe indawo ngamaqembu amabili e-methyl endaweni engu-9. Le nhlanganisela ibaluleke kakhulu ekuhlanganisweni kwezinto eziphilayo, ikakhulukazi ekuphenduleni kwe-Suzuki-Miyaura cross-coupling, lapho isebenza khona njenge-reagent ye-boronic acid eguquguqukayo. Ngaphezu kwalokho, isakhiwo sayo esiqinile nesivinjiwe senza sibe yigugu ekwakhiweni kwe-ligand ekuphenduleni kwe-transition metal-catalyzed kanye nasekuthuthukisweni kwezinto ezisebenzayo.
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I-4-Carboxyphenylboronic acid I-CAS: 14047-29-1
I-4-Carboxyphenylboronic acid, eyaziwa nangokuthi i-4-Carboxyphenylboronic acid noma i-4-CPBA, iyinhlanganisela yamakhemikhali eyingxenye yesigaba sama-asidi e-boronic. Ibonakala ngeqembu layo elisebenzayo le-boronic acid (-B(OH)₂) elinamathiselwe endandatho ye-phenyl ethathelwe indawo yiqembu le-carboxylic acid (-COOH) endaweni ye-para. Le nhlanganisela ithola ukusetshenziswa okubanzi ekuhlanganisweni kwezinto eziphilayo, ikakhulukazi ekuphenduleni kwe-Suzuki-Miyaura cross-coupling ukwakha izibopho ze-carbon-carbon. Ngaphezu kwalokho, ikhono layo lokubopha kuma-diols noshukela liholele ekusetshenzisweni kwayo ekuthuthukisweni kwezinzwa zokuqapha i-glucose kanye namakhemikhali ezokwelapha ukuklama ama-enzyme inhibitors nama-receptor ligands.
