I-Fidaxomicin CAS:873857-62-6

I-Fidaxomicin isetshenziswa kakhulu ekwelapheni ukutheleleka kwe-Clostridioides difficile, ikakhulukazi ezimweni ze-CDI ephakathi nendawo kuya kwenzima lapho ukwelashwa kwendabuko bekungaphumeleli kahle khona noma kuhlotshaniswa namazinga aphezulu okuphindaphinda. Inikezwa ngomlomo ngesimo sethebhulethi, okuvumela ukulethwa okuqondisiwe endaweni yokutheleleka ku-colon. Indlela eyingqayizivele yokusebenza kwe-fidaxomicin ihilela ukuvimbela i-RNA polymerase yamabhaktheriya, ukuphazamisa ukwakheka kwamaprotheni kumaseli e-C. difficile. Ngokubhekisisa le pathogen ethile ngaphandle kokuthinta i-microbiota ezuzisayo yamathumbu, i-fidaxomicin isiza ukubuyisela ibhalansi yamagciwane ku-colon futhi inciphise ingozi yeziqephu ze-CDI eziphindaphindayo. Iziguli ezinegciwane le-C. difficile eliqinisekisiwe noma elisolwayo zivame ukunikezwa i-fidaxomicin isikhathi esithile kuye ngokuthi ukutheleleka kungakanani. Ukunamathela kumthamo kanye nohlelo olubekiwe kubalulekile ekufinyeleleni imiphumela emihle yezokwelapha kanye nokunciphisa ingozi yokuphindaphinda. Imiphumela emibi evamile ingafaka isicanucanu, ubuhlungu besisu, kanye nokuphazamiseka kwesisu; noma kunjalo, i-fidaxomicin ngokuvamile ibonisa ukubekezeleleka okuhle uma kuqhathaniswa nezinye izindlela zokwelapha ze-CDI. Ukuqapha njalo ngesikhathi sokwelashwa kanye nokuhlolwa kokulandelela ngemuva kokwelashwa kubalulekile ukuhlola impendulo, ukuqapha ukusabela okubi, kanye nokuvimbela ukubuyela emuva kokutheleleka kwe-C. difficile. Abahlinzeki bezempilo badlala indima ebalulekile ekuqondiseni ukusetshenziswa okufanele kwe-fidaxomicin ukuphatha i-CDI ngempumelelo nokukhuthaza ukululama kwesiguli.