i-dUMP, i-2′-Deoxyuridine-5′-monophosphate, usawoti we-disodium I-CAS:42155-08-8

Ukwenziwa kwe-DNA: i-dUMP isebenza njengesandulela se-deoxythymidine triphosphate (dTTP), ebalulekile ekuphindaphindweni kwe-DNA. Ukuguqulwa kwe-dUMP ibe yi-dTMP kuyisinyathelo esibalulekile ekwakhiweni kwama-nucleotide e-thymidine, abalulekile ekuphindaphindweni okunembile kwezinto zofuzo ngesikhathi sokuhlukaniswa kwamaseli.

I-Thymidylate Biosynthesis: i-dUMP iyi-substrate ye-enzyme i-thymidylate synthase, ekhuthaza ukuguqulwa kwe-dUMP ibe yi-dTMP. Le nqubo ibalulekile ekugcineni ibhalansi efanele ye-nucleotide emaseli nokuqinisekisa ukwethembeka kokuphindaphindwa kwe-DNA.

Inhloso Yomuthi Wokulwa Nomdlavuza: I-Thymidylate synthase, i-enzyme ehilelekile ekuguqulweni kwe-dUMP ibe yi-dTMP, iyinhloso yemithi ethile yokulwa nomdlavuza. Ukuvimbela i-thymidylate synthase kungaphazamisa ukwakheka kwe-DNA kanye nokwanda kwamaseli, okwenza kube yinhloso engaba khona ye-chemotherapy.

Ithuluzi Lokucwaninga: i-dUMP isetshenziswa ocwaningweni lwe-biochemical kanye ne-molecular biology njengesisekelo sokutadisha izindlela zokwenziwa kwe-DNA, ukulungiswa, kanye ne-metabolism ye-nucleotide. Iphinde isetshenziswe ekuhlolweni kwe-enzyme ukuphenya umsebenzi we-thymidylate synthase kanye nama-enzyme ahlobene nawo.