Umhlinzeki Womkhiqizi we-Duloxetine HCL CAS:136434-34-9

I-Duloxetine HCL uhlobo lukasawoti lomuthi wokucindezeleka i-duloxetine. Yakhiwe ngempumelelo yi-Eli Lilly Company. Umphumela wayo wezokwelapha ufana nowe-duloxetine. I-Duloxetine hydrochloride uhlobo olusha lokuvimbela okubili okukhethiwe kwe-5 hydroxy trptamine (5-HT) kanye ne-norepinephrine reuptake, futhi ngaleyo ndlela inomphumela wokucindezeleka, kuyilapho futhi inomphumela wokuvimbela ebuhlungwini obuphakathi. Isici sayo sezokwelapha ukukwazi ukuvimbela ukuphinda kuthathwe kwe-neuronal pre-synaptic membrane ku-5-hydroxy trptamine kanye ne-norepinephrine kodwa esikhundleni salokho ibe nomphumela ophansi wokuvimbela ekuphindweni kwe-dopamine. I-Duloxetine hydrochloride iboniswa ukucindezeleka futhi iyasebenza ekwelapheni ukucindezeleka okungokwemvelo nokungekona okwemvelo kanye nomuzwa wobuhlungu obuhambisana nokucindezeleka. Inomthamo wokwelapha ongu-60mg/ngosuku ~ 120mg/ngosuku ngokuphepha okuhle kanye nokusabela okuncane okubi okunemiphumela emibi evamile njengesicanucanu, umlomo owomile, ukuqunjelwa, ukungakuthandi ukudla, ukukhathala, ukozela, kanye nokujuluka okukhulu. Esinye isibonakaliso ubuhlungu obubangelwa yi-neuropathy yesifo sikashukela.