I-Boc-Trp-OSu CAS:3392-11-8

I-Boc-Trp-OSu ibalulekile kumakhemikhali e-bioconjugation, ikakhulukazi ekusebenzeni kwama-peptide namaprotheni ukuze kusetshenziswe okuqondiwe. Njenge-derivative ye-NHS ester, yenza kube lula ukuhlanganiswa kwe-covalent kwe-Boc-protected tryptophan moiety nama-amine ayinhloko akhona kuma-amino acid, ama-peptide, noma amaprotheni. Lokhu kuhlanganiswa okukhethiwe kuvumela ukuguqulwa okunembile kwezinsalela ezithile ze-amino acid ngaphakathi kochungechunge lwe-peptide noma i-N-terminus yeprotheni, okuvumela ukwethulwa kwamaqembu asebenzayo noma amalebula ngezinhloso ezahlukahlukene. Abacwaningi kanye nososayensi be-biochem basebenzisa i-Boc-Trp-OSu ekuthuthukisweni kwama-peptide conjugates ezicelo ezifana nokulethwa kwemithi okuqondiwe, ukuhlolwa kwe-immunoassays, kanye nokusebenza kwe-biomaterial. Ngokuhlanganisa ama-peptide aguquliwe e-Boc-Trp-OSu kuma-molecule noma ezindaweni eziqondiwe, bangakha izakhiwo ze-bioactive ezikwazi ukusebenzisana ngokukhetha nama-receptor eselula, ama-antigen, noma ama-matrices e-biological. Ngaphezu kwalokho, i-Boc-Trp-OSu isetshenziswa ekulungiseleleni ama-conjugates e-peptide-protein ekwakheni ama-conjugates e-antibody-drug (ama-ADC) kanye nokulebula amaprotheni ukuze kuthathwe izithombe kanye nokuhlolwa kokuxilonga. Ukuguquguquka kwe-Boc-Trp-OSu kuyenza ibe ithuluzi elibalulekile emikhakheni eyahlukene njenge-chemistry biology, i-biotechnology, kanye nesayensi yezemithi. Ukuhambisana kwayo nezinqubo ze-bioconjugation, ukusebenza okuphezulu, kanye nokukhetha kunegalelo ekusetshenzisweni kwayo kabanzi ezindaweni zezemfundo nezezimboni. Kungakhathaliseki ukuthi isetshenziswa ocwaningweni oluyisisekelo noma ekuthuthukisweni kwezindlela zokwelapha ezithuthukisiwe, i-Boc-Trp-OSu ivumela ukudalwa kwama-conjugates e-peptide aklanyelwe wona abalulekile ekuthuthukiseni ukwelashwa okuqondiwe kanye nokuxilongwa kwama-molecule.