I-Boc-Lys(Z)-OSu CAS:34404-36-9

I-Boc-Lys(Z)-OSu isetshenziswa kakhulu ezinqubweni zokuguqulwa kwe-bioconjugation kanye ne-peptide. Ekuhlanganisweni kwe-peptide, isetshenziselwa ukwethula izinsalela ze-lysine ezindaweni ezithile ngaphakathi kochungechunge lwe-peptide, okuvumela ukunamatheliswa kwamaqembu asebenzayo, amalebula, noma amanye ama-molecule ukuze kusetshenziswe ngezindlela ezahlukene. Lokhu kuguqulwa okukhethiwe kuvumela ukudalwa kwama-peptide asebenzayo amaningi anezakhiwo eziklanyelwe wona, njengokuqina okuthuthukisiwe, ukucaciswa kwenhloso, noma amakhono okuthwebula izithombe. Ngaphezu kwalokho, ocwaningweni lwe-proteomics, i-Boc-Lys(Z)-OSu yenza kube lula ukulebula amaprotheni nama-peptide endaweni ethile ukuze kuhlaziywe isakhiwo, izifundo zokusebenzisana, kanye nokuhlolwa kwe-proteomic okusekelwe ku-mass spectrometry. Ukunamatheliswa okulawulwayo kwe-Boc-Lys(Z)-OSu kuma-residue e-lysine kwenza kube nokuhlukaniswa okunembile kanye nokuhlaziywa kokusebenza kwamaprotheni nama-peptide, ngaleyo ndlela kufake isandla ekuthuthukisweni kokuqonda izinhlelo zezinto eziphilayo kanye nezindlela zezifo. Ngaphezu kwalokho, emkhakheni wokuthuthukiswa kwemithi, i-Boc-Lys(Z)-OSu idlala indima ebalulekile ekuhlanganiseni izinto zokwelapha kuma-peptide noma amaprotheni, ngaleyo ndlela idale izinhlelo zokulethwa kwemithi eziqondiwe, ama-antibody-drug conjugates, noma izakhiwo zomuthi wokugoma ezinephrofayili ye-pharmacokinetic ethuthukisiwe kanye nemiphumela encishisiwe engaqondile. Sekukonke, ukuguquguquka kwe-Boc-Lys(Z)-OSu kanye nokuthembeka ekuguqulweni kwe-peptide kanye ne-bioconjugation kwenza kube ithuluzi elibalulekile lokuthuthukisa ucwaningo ekutholakaleni kwemithi, i-chemistry biology, kanye ne-proteomics, okunikeza amathuba ahlukahlukene okuthuthukisa izinhlelo zokusebenza ezintsha ze-biomedical.