I-Boc-Asp(OBut)-ONp CAS:29365-05-7

I-Boc-Asp(OBut)-ONp isetshenziswa kakhulu ekuhlanganisweni kwe-peptide ekukhiqizweni kwama-peptide enziwe ngokwezifiso anemisebenzi ethile. Njenge-derivative ye-L-aspartic acid, yenza kube lula ukuhlanganiswa okulawulwayo kwezakhiwo ze-peptide eziyinkimbinkimbi ngokusebenza njenge-ester esebenzayo yokusabela kokuhlanganisa ngesikhathi sokuhlanganiswa kwe-peptide yesigaba esiqinile (i-SPPS). Le nqubo ibalulekile ekutholakaleni nasekuthuthukisweni kwemithi, kanye nasezifundweni ze-biochemical ezihlose ukuqonda ukusebenzisana kwamaprotheni kanye nezindlela zokubonisa izimpawu. Ngaphezu kwalokho, i-Boc-Asp(OBut)-ONp idlala indima ebalulekile ekudalweni kwemitapo yolwazi ye-peptide yokuhlola izidakamizwa nokwenza ngcono i-lead. Ubumsulwa bayo obuphezulu kanye nekhwalithi ehambisanayo kuqinisekisa ukuthembeka nokuphindaphinda ezinqubweni zocwaningo, okunikela ekuthuthukisweni emikhakheni esukela kumakhemikhali ezokwelapha kuya kubuchwepheshe be-bio. Ngamafuphi, i-Boc-Asp(OBut)-ONp ibalulekile ekuthuthukisweni kokutholwa kwesayensi nezokwelapha ngokuvumela ukuhlanganiswa kwama-peptide ayinkimbinkimbi anezakhiwo ezilungiselelwe, ekugcineni kusekela ukuthuthukiswa kwemithi emisha kanye nezidakamizwa zokwelapha. Ukuguquguquka kwayo kanye nokusetshenziswa kwayo kabanzi ocwaningweni lwemithi kugcizelela ukubaluleka kwayo njengethuluzi eliwusizo kososayensi nabacwaningi emhlabeni jikelele.