i-beta-Nicotinamide adenine dinucleotide trihydrate CAS:53-84-9

Ukukhiqizwa kwamandla: i-β-NAD+ iyisici esibalulekile enkambisweni yokuguqula ukudla kube amandla. Isebenza njenge-coenzyme ekuphefumuleni kwamaseli, ikhuthaza ukudluliselwa kwama-electron kusuka kuma-metabolites kuya kuchungechunge lokuthuthwa kwama-electron. Lokhu kudluliselwa kwama-electron kubalulekile ekukhiqizweni kwe-ATP, okuyimali yamandla eyinhloko yamaseli.

Ukulungiswa kwe-DNA: I-β-NAD+ ihilelekile ezinqubweni zokulungiswa kwe-DNA. Isebenza njengesisekelo sama-enzyme afana nama-PARP (i-Poly [ADP-ribose] polymerases), asebenzisa i-β-NAD+ ukulungisa i-DNA eyonakele ngenxa yokucindezeleka okuhlukahlukene kwamangqamuzana njengomonakalo we-DNA obangelwa imisebe, ubuthi, noma ukucindezeleka kwe-oxidative.

Ukubonisana kweselula: I-β-NAD+ ivele njenge-molecule ebalulekile yokubonisana ehilelekile ezindleleni ezahlukene zamaseli. Ingasebenza njengesandulela sama-molecule ahlukene okubonisana, njenge-cyclic ADP-ribose kanye ne-NAADP, elawula ukukhishwa kwe-calcium kanye nokudluliselwa kwesignali. Ngaphezu kwalokho, i-β-NAD+ metabolism ingathonya ukuvezwa kwezakhi zofuzo, ukuguga, kanye nezinye izinqubo zomzimba.

Izicelo zokwelapha: Ukwengezwa kwe-β-NAD+ kanye nokuguqulwa kwamazinga e-β-NAD+ kuyaphenywa ngezicelo zokwelapha ezingaba khona. Izifundo zakamuva ziphakamisa ukuthi ukwanda kwamazinga e-β-NAD+ kungaba nemiphumela emihle ezifweni ezihlobene nokuguga, izifo ze-neurodegenerative, izinkinga ze-metabolic, kanye nempilo yenhliziyo. Kukhona nocwaningo oluqhubekayo mayelana nokusetshenziswa kwezinto ezandulela i-β-NAD+, njenge-nicotinamide riboside kanye ne-nicotinamide mononucleotide, njengezithasiselo ezingaba khona zokwandisa amazinga e-β-NAD+ emzimbeni.