I-Ansamycin CAS:72559-06-9

Ama-ansamycin, njenge-rifamycins, avame ukusetshenziswa emitholampilo ukwelapha izifo ezahlukahlukene zamagciwane, okuhlanganisa isifo sofuba, uchoko, kanye nezinhlobo ezithile zokutheleleka kwe-staphylococcal kanye ne-streptococcal. I-Rifampin, i-rifamycin eyaziwayo, ivame ukusetshenziswa njengengxenye yokwelapha okuhlanganisiwe kwesifo sofuba kanye nezinye izifo ze-mycobacterial. Indlela yokusebenza kwama-ansamycins ihilela ukubopha ku-RNA polymerase yamagciwane, ngaleyo ndlela kuvimbele ukubhalwa kwemithi futhi ekugcineni kuholele ekufeni kwamaseli amagciwane. Le ndlela eyingqayizivele yokusebenza yenza ama-ansamycin asebenze kahle ngokumelene nohlu olubanzi lwamagciwane ane-Gram-positive kanye ne-Gram-negative. Abahlinzeki bezempilo bacabangela ngokucophelela izici ezifana nohlobo lokutheleleka, umlando wezokwelapha wesiguli, kanye nemiphumela yokuhlolwa kokuzwela kwamagciwane lapho benikeza ama-ansamycins. Umthamo ofanele, isikhathi sokwelashwa, kanye nokuqapha imiphumela emibi engaba khona kubalulekile ekwandiseni izinzuzo zokwelapha ngenkathi kunciphisa izingozi ezihlobene nokusetshenziswa kwama-antibiotic. Imiphumela emibi ehlobene nama-ansamycins ingafaka ukuphazamiseka kwesisu, ubuthi besibindi, kanye nokusabela kokucindezeleka. Ukuqapha njalo ukuhlolwa kokusebenza kwesibindi kanye nokuqaphela ngokucophelela noma yiziphi izimpawu zokusabela okubi kusiza ukuqinisekisa ukusetshenziswa okuphephile nokuphumelelayo kwama-ansamycin ekwelapheni ukutheleleka ngamagciwane. Sekukonke, ama-ansamycin amelela uhlobo olubalulekile lwama-antibiotic anezinhlelo ezahlukene zokuphatha ukutheleleka ngamagciwane. Ngokusebenzisa nokuqapha okufanele, ochwepheshe bezempilo bangasebenzisa izakhiwo zokulwa namagciwane zama-ansamycin ukulwa nokutheleleka ngempumelelo nokuthuthukisa imiphumela yeziguli.