I-Amphotericin B – Ibanga lomjovo i-CAS:1397-89-3

Umjovo we-Amphotericin B usetshenziswa ekwelapheni izifo ezingathi sína zesikhunta ezifana ne-candidemia, i-aspergillosis ehlaselayo, i-cryptococcal meningitis, kanye ne-mucormycosis, ikakhulukazi ezigulini ezikhubazekile noma lezo ezinezivikeli mzimba ezibuthakathaka. Ngenxa yomsebenzi wayo onamandla wokulwa nezifo, umjovo we-amphotericin B uvame ukubhekwa njengokwelashwa kokuqala kwezifo ezingathi sína zesikhunta. Ochwepheshe bezempilo banikeza i-amphotericin B ngemithambo, beqapha ngokucophelela iziguli ngesikhathi sokufakwa ukuze baphathe imiphumela emibi engaba khona, okuhlanganisa umkhuhlane, ukubanda, kanye nokusabela okuhlobene nokufakwa. Umthamo kanye nobude bokwelashwa kwe-amphotericin B kulungiselelwe ukutheleleka kwesikhunta okuthile, isimo sezokwelapha sesiguli, kanye nanoma yikuphi ukungasebenzi kahle kwesitho esingaphansi. Njengoba i-nephrotoxicity yayo kanye namathuba okuphazamiseka kwe-electrolyte, ukuqapha eduze ukusebenza kwezinso kanye namazinga e-electrolyte kubalulekile ngesikhathi sokwelashwa kwe-amphotericin B. Ukwakheka kwe-lipid kwe-amphotericin B kungasetshenziswa ukunciphisa ubuthi bezinso kanye nokusabela okuhlobene nokufakwa okuhlobene nokufakwa okuhlobene ne-amphotericin B deoxycholate evamile. Ukuqapha njalo imiphumela emibi, njengokukhubazeka kwezinso kanye ne-hypokalemia, kanye nokunakekelwa okufanele okusekelayo, kusiza ukuphatha ukuphepha nokubekezeleleka kokwelashwa kwe-amphotericin B. Abahlinzeki bezempilo balinganisa ngokucophelela izinzuzo zokwelashwa ngokumelene nezingozi ezingaba khona, baqinisekise ukuthi iziguli zithola ukwelashwa okune-antifungal okufanele ngenkathi zinciphisa umthelela wemiphumela emibi. Ngokubhekana ngempumelelo nokutheleleka okukhulu kwe-fungus emzimbeni, umjovo we-amphotericin B udlala indima ebalulekile ekubhekaneni nezimo ezisongela ukuphila kanye nokuhlinzeka ngezinketho zokwelapha iziguli ezibhekene nezifo ze-fungus eziyinselele.