I-Adenosine CAS:58-61-7

Embonini yezemithi, i-adenosine isetshenziselwa izakhiwo zayo zemithi, ikakhulukazi ekwelapheni ama-arrhythmia athile enhliziyo. Inikezwa ngemithambo yegazi ukuze kubuyiselwe isigqi senhliziyo esijwayelekile ngesikhathi seziqephu ze-supraventricular tachycardia. Ngaphezu kwalokho, imiphumela ye-vasodilatory ye-adenosine inegalelo ekusetshenzisweni kwayo ezinqubweni zokuxilonga ezifana nokuhlolwa kokucindezeleka kwesifo semithambo yenhliziyo, lapho isiza khona ekubangeleni ukujikeleza kwegazi okulawulwayo kwenhliziyo ukuhlola ukugeleza kwegazi kwenhliziyo. Ngaphandle kokusetshenziswa kwenhliziyo, i-adenosine isebenza njengesisulu esibalulekile ekuthuthukisweni kwemithi, abacwaningi behlola amandla ayo ekubhekaneni nezimo ezisukela ezifweni eziwohlokayo zemizwa kuya kumdlavuza. Ukubandakanyeka kwayo ekulawuleni ukukhululwa kwe-neurotransmitter kanye nomsebenzi we-synaptic kuholele ekuphenyweni kwezindlela zokwelapha ezisekelwe ku-adenosine zezifo zezinzwa kanye nezimo zengqondo. Ngaphezu kwalokho, i-adenosine kanye nezinye izinto ezifanayo zifundwa ngemiphumela yazo yokulawula amasosha omzimba, kanye nemiphumela yezifo ezizimele, ukuvuvukala, kanye nomuthi wokufakelwa. Ngokuqondisa ama-receptor e-adenosine, abacwaningi bahlose ukusebenzisa izakhiwo zokucindezela amasosha omzimba kanye nokulwa nokuvuvukala kwe-adenosine njengesisekelo sokuthuthukisa ukwelashwa okusha. Ngamafuphi, izindima eziningi ze-adenosine ezihlanganisa ukwakheka kwamandla, ukusebenza kwenhliziyo, ukudluliselwa kwemizwa, kanye nokuguqulwa kwamasosha omzimba kugcizelela ukubaluleka kwayo ocwaningweni lwemithi kanye nezicelo zokwelapha, okuhlinzeka ngendlela ecebile yokuthuthukisa ukungenelela kwezokwelapha kanye nokwandisa ukuqonda kwethu izindlela zamaseli nezomzimba.