I-Acetylthiocholine iodide CAS:1866-15-5

I-Acetylthiocholine iodide isetshenziswa kakhulu njenge-substrate ukukala umsebenzi we-enzyme i-acetylcholinesterase (AChE). I-AChE inesibopho sokuphula i-neurotransmitter acetylcholine ohlelweni lwezinzwa. Ukwengezwa kwe-acetylthiocholine iodide engxubeni yokusabela equkethe i-AChE kuholela ekukhiqizweni kwe-thiocholine ne-acetate.

Ukusabela kungatholakala ngokungeza inkomba ye-colorimetric noma ye-fluorometric ephendula ngqo ne-thiocholine. Izinga lokukhiqizwa kombala noma kwe-fluorescence lilingana ngqo nomsebenzi we-AChE kusampula. Lokhu kwenza i-acetylthiocholine iodide ibe ithuluzi eliwusizo lokulinganisa umsebenzi we-AChE kumasampula ahlukahlukene ebhayoloji, kufaka phakathi izicubu, amasiko amaseli, kanye negazi.

Ukulinganiswa komsebenzi we-AChE kusetshenziswa i-acetylthiocholine iodide kusetshenziswa kabanzi ezifundweni zocwaningo ezihlobene nezinhlelo ze-cholinergic, izifo ze-neurodegenerative, kanye nokuchayeka kumakhemikhali athile noma izidakamizwa ezingathinta umsebenzi we-AChE. Kungasetshenziswa futhi njengethuluzi lokuhlola ukuthola ama-AChE inhibitors, anentshisekelo ekuthuthukisweni kwemithi yezifo ezifana ne-Alzheimer's kanye ne-Parkinson's.

Ngaphezu kokusetshenziswa ekuhlolweni kwe-enzyme, i-acetylthiocholine iodide ingasetshenziswa futhi njengesisekelo sama-biosensors asekelwe ku-AChE. Lawa ma-biosensors aklanyelwe ukuthola nokulinganisa ukuba khona kwezinto ezithile ezingavimbela umsebenzi we-AChE, njengezibulala-zinambuzane ze-organophosphate noma ama-nerve agents.