3,6,9,12-tetraazatetradecamethylenediamine CAS:4067-16-7

I-3,6,9,12-tetraazatetradecamethylenediamine (i-spermine) isebenza njenge-biomolecule ebalulekile ehilelekile ezinqubweni ezahlukene zezinto eziphilayo. Idlala indima ebalulekile ekukhuleni kwamaseli, ekwandeni kwawo, kanye nasekuzinzisweni kwe-DNA, inegalelo emisebenzini ebalulekile yamaseli. Ukuba khona kwesidoda ezintweni eziphilayo kugcizelela ukubaluleka kwayo ekugcineni ubuqotho bamaseli kanye nokulawula izinqubo zomzimba. Ngaphezu kwalokho, isidoda sisetshenziswa ocwaningweni lwe-molecular and cell biology njenge-reagent yezifundo ze-nucleic acid kanye namaprotheni. Amandla aso okusebenzisana ne-DNA, i-RNA, kanye namaprotheni enza abacwaningi bakwazi ukuhlola izindlela zama-molecule, ukulawulwa kokubonakaliswa kwezakhi zofuzo, kanye nesakhiwo se-chromatin, okwenza kube lula ukuqonda okujulile kwezinqubo eziyisisekelo zezinto eziphilayo. Ngaphezu kwalokho, isidoda sithola ukusetshenziswa ekuthuthukisweni kwemithi kanye nezinhlelo zokulethwa kwemithi ngenxa yokusebenzisana kwaso nama-nucleic acid kanye nemiphumela engaba khona ekwelashweni kwezakhi zofuzo kanye nezindlela zokwelapha ezisekelwe ku-nucleic acid. Indima yaso ekuguquleni izakhiwo nemisebenzi ye-nucleic acid igcizelela ukubaluleka kwaso ekuthuthukisweni kwezindlela zokwelapha ezintsha kanye nobuchwepheshe bezokwelapha. Ngaphezu kwalokho, ukubandakanyeka kwe-spermine ekwakhiweni kwe-complexes ezizinzile nemithi ethile kanye nama-biomolecule kugqamisa amandla ayo njenge-scaffold yama-molecule yokulethwa kwemithi okuqondiwe kanye nokungenelela kokwelapha. Izakhiwo zayo eziyingqayizivele ziyibeka njengomuntu othembisayo ekuthuthukiseni amafomu amasha emithi kanye nezinhlelo zokusebenza ze-biotechnological. Ngamafuphi, i-3,6,9,12-tetraazatetradecamethylenediamine (spermine) idlala indima ebalulekile ezinqubweni zezinto eziphilayo, ucwaningo lwama-molecule, kanye nokuthuthukiswa kwemithi, isebenza njenge-molecule enezici eziningi enemiphumela ebanzi kwezesayensi yokuphila kanye nentuthuko yezokwelapha.