(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride CAS:188416-35-5

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride isetshenziswa kumakhemikhali okwelapha ngenxa yemisebenzi yayo engaba khona yezokwelapha kanye nezicelo zokwelapha. Le khompawundi ingabonisa izakhiwo zokulwa nokwanda, zokulwa nokuvuvukala, noma zokuvimbela ama-enzyme eziwusizo ekwelapheni izifo ezahlukahlukene, okuhlanganisa umdlavuza, ukuvuvukala, kanye nezimo ezithelelanayo. Ekutholakaleni kwemithi, abacwaningi basebenzisa i-(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride ukuklama nokuhlanganisa amakhemikhali amasha ngamandla athuthukisiwe, ukukhetha, kanye nokutholakala kwezinto eziphilayo. Ngokushintsha isakhiwo sayo samakhemikhali nokuhlola ubudlelwano besakhiwo nomsebenzi, ososayensi bahlose ukuthuthukisa ama-ejenti amasha okwelapha aqondisa izindlela ezithile zama-molecule kanye nezinhloso zezinto eziphilayo ezithintekayo ezifweni. Ngaphezu kwalokho, le khompawundi isebenza njengesikafu sama-molecule sokuhlanganiswa kwamakhemikhali angaba khona anephrofayili ye-pharmacokinetic ethuthukisiwe kanye nokusebenza kahle kokwelapha okuthuthukisiwe. Ukusebenzisana kwayo nezinhloso zamaseli, izindlela zokubonisa izimpawu, kanye nama-biomarker ezifo kunikeza ukuqonda ngemiphumela yayo yezinto eziphilayo kanye nezindlela zokusebenza, kuqondise ukuthuthukiswa kwezindlela zokwelapha eziqondiwe kanye nokwelashwa okwenziwe ngezifiso kweziguli ezinezidingo zezokwelapha ezingakahlangatshezwa. Ngaphezu kwalokho, i-(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride ingasetshenziswa ezifundweni zangaphambi kokwelashwa ukuhlola ukuphepha kwayo, ukusebenza kahle, kanye nezakhiwo zezokwelapha ngaphambi kokuqhubekela ezivivinyweni zezokwelapha. Ukusebenza kwayo kwe-bioactivity, imiphumela ye-pharmacodynamic, kanye nemiphumela emibi engaba khona kuhlolwa ukuze kunqunywe amandla ayo okwelapha kanye nokufaneleka kokuthuthuka okuqhubekayo njengomkhiqizo wezokwelapha. Sekukonke, i-(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride imele inhlanganisela ebalulekile ocwaningweni lwe-chemistry yezokwelapha, inikeza amathuba okuthola imithi, ukwenza ngcono i-lead, kanye nokusungula izindlela zokwelapha emzamweni wokubhekana nezimo zezokwelapha eziyinkimbinkimbi nokuthuthukisa imiphumela yeziguli.