(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-[4-chloro-3-(4-ethoxybenzyl)phenyl]tetrahydropyran-3,4,5-triyl I-Triacetate I-CAS:461432-25-7

I-Triacetate ihlanganiswe ngezindlela eziyinkimbinkimbi zezinto eziphilayo, (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-[4-chloro-3-(4-ethoxybenzyl)phenyl]tetrahydropyran-3,4,5-triyl Triacetate inokwakheka kwama-molecule okuhlukile okubalulekile ekusetshenzisweni kwayo okuhlukahlukene. Uhlaka lwe-tetrahydropyran, kanye ne-acetoxymethyl kanye ne-4-chloro-3-(4-ethoxybenzyl)phenyl, kuthonya ukusabela kwayo, ukuncibilika, kanye nokuhambisana kwayo ezindaweni ezahlukahlukene zamakhemikhali. Ukusetshenziswa Kokwenziwa Kwezinto Eziphilayo Le khompawundi isebenza njengesakhiwo esiguquguqukayo ekuhlanganisweni kwezinto eziphilayo, ikhuthaza ukwakhiwa kwama-molecule ayinkimbinkimbi ngenxa yobunzima besakhiwo sayo kanye namaqembu asebenzayo. I-scaffold ye-tetrahydropyran inikeza ubuqotho besakhiwo kanye nokuqina, isiza ekuphenduleni okulawulwayo kanye nokuguqulwa kwe-stereoselective. Izimfanelo ezinjalo zibalulekile ekuhlanganisweni kwemikhiqizo yemvelo kanye nezidakamizwa eziphakathi. Amandla Ezokwelapha Ukuba khona kwendandatho ye-phenyl ene-chloro kanye namaqembu e-4-ethoxybenzyl kusikisela imisebenzi engaba khona yezokwelapha. Ucwaningo lugxile ekuhloleni indima yalo njengenhlanganisela eholayo noma i-pharmacophore yokuthuthukiswa kwemithi, luhlose izindlela ezithile zezinto eziphilayo noma ama-receptor. Iqembu le-acetoxymethyl lingasebenza njengesu leqembu elivikelayo kumakhemikhali wezokwelapha, lithuthukise ukuzinza kanye nokulethwa okuqondiwe ekwakhiweni kwemithi. Izicelo Zesayensi Yezinto Ezibalulekile Kwisayensi yezinto ezibonakalayo, i-(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-[4-chloro-3-(4-ethoxybenzyl)phenyl]tetrahydropyran-3,4,5-triyl I-Triacetate inegalelo ekuthuthukisweni kwezindawo ezisebenzayo kanye ne-polymer chemistry. Isakhiwo sayo samakhemikhali esilungiselelwe sinikeza amathuba okuguqulwa kwendawo kanye nokuhlanganiswa kuma-matrices e-polymeric, okuthuthukisa izakhiwo ezifana nokunamathela, amandla omshini, kanye nokuhambisana kwezinto eziphilayo ezintweni zezinhlelo zokusebenza ezahlukahlukene. Izifundo Zemiphumela Yezokwelapha zihlola amandla ayo ekusetshenzisweni kwezokwelapha, zisebenzisa izici zayo zesakhiwo zokuthuthukisa izinhlelo zokulethwa kwemithi noma izembozo ze-bioactive. Amasu okusebenza ngale nhlanganisela ahlose ukuthuthukisa ukusebenza kahle kokwelapha, ukuhambisana kwezinto eziphilayo, kanye nokusebenzisana okuqondisiwe nezinhlelo zezinto eziphilayo, ngaleyo ndlela kuthuthukiswe ubuchwepheshe bedivayisi yezokwelapha kanye nezindlela zokwelapha. Ukwenziwa Nokuthuthukiswa Ukwenziwa kwe-(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-[4-chloro-3-(4-ethoxybenzyl)phenyl]tetrahydropyran-3,4,5-triyl Triacetate kuhilela imizila yokwenziwa eyinkimbinkimbi yezinto eziphilayo eqala ezintweni ezitholakala kwezentengiselwano. Ukwenza ngcono le mizila kubalulekile ekufinyeleleni ubumsulwa obuphezulu kanye nesivuno, okubalulekile kokubili ocwaningweni kanye nezicelo zezimboni. Ukuthuthukiswa okuqhubekayo kuhlose ukwenza lula ukwenziwa komkhiqizo ukuze kukhiqizwe ngendlela engabizi futhi eqhubekayo. Ucwaningo Lwamanje Neziqondiso Zesikhathi Esizayo Izinhlelo zocwaningo zamanje zihlose ukwandisa ukusetshenziswa kwe-compound kumithi yezokwelapha, isayensi yezinto, kanye ne-biotechnology. Iziqondiso zesikhathi esizayo zifaka phakathi ukuhlola ukusebenza kwayo ezinhlelweni zokulethwa kwemithi eziqondiwe, ukuthuthukisa ukuhambisana kwayo nezixhumi zebhayoloji, kanye nokwenza ngcono ukuguqulwa kwayo kwamakhemikhali kwezicelo ezithile zokwelapha. Ngaphezu kwalokho, imizamo igxile ekucaciseni izindlela zayo zokusebenza kanye nokuthuthukisa izindlela zokwenziwa ukuze kuhlangatshezwane nezidingo zesayensi nezezimboni ezishintshayo. Isiphetho Ekuphetheni, i-(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-[4-chloro-3-(4-ethoxybenzyl)phenyl]tetrahydropyran-3,4,5-triyl I-Triacetate imele inhlanganisela enezici eziningi enemiphumela ebalulekile ekuhlanganisweni kwezinto eziphilayo, ucwaningo lwemithi, kanye nesayensi yezinto ezibonakalayo. Isakhiwo sayo esiyinkimbinkimbi sama-molecule, esihlanganisa ukusebenza kwe-tetrahydropyran, phenyl, kanye ne-acetoxymethyl, sigcizelela ukuguquguquka kwayo kanye nekhono layo lokusungula izinto ezintsha emikhakheni eyahlukene yezobuchwepheshe. Ukuqhubekisela phambili ucwaningo ezimpahleni zalo, izinhlelo zokusebenza, kanye nezindlela zokwenziwa kuthembisa ukuvula amathuba amasha okubhekana nezinselele eziyinkimbinkimbi kumakhemikhali, kwezokwelapha, nangale kwalokho.