2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate CAS:86520-63-0

I-2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl I-2,2,2-trichloreacetimidate iyinhlanganisela yamakhemikhali evame ukusetshenziswa kumakhemikhali e-carbohydrate kanye nokusabela kwe-glycosylation. Ivela ku-α-D-galactopyranose, uhlobo lukashukela, lapho amaqembu e-hydroxyl ezindaweni ezingu-2, 3, 4, kanye no-6 zendandatho ye-galactopyranose e-acetylated. Ngaphezu kwalokho, i-anomeric carbon (C1) kashukela ivikelwe yiqembu le-trichloroacetimidate, elenza libe yi-electrophile enamandla ngesikhathi sokusabela kwe-glycosylation.

Le nhlanganisela ivame ukusetshenziswa njenge-ejenti ye-glycosylating ukwethula izingxenye ze-galactose kuma-molecule ahlukahlukene, njengeprotheni, ama-peptide, noma ama-molecule amancane e-organic. Lokhu kungafezwa ngokuphendula le nhlanganisela nge-nucleophile (isb., amaqembu e-hydroxyl ku-molecule eqondiwe) ngaphansi kwezimo ezifanele. Iqembu le-trichloroacetimidate lenza kube lula ukunamatheliswa kwengxenye ye-galactose ku-molecule eqondiwe, okuholela ekwakhekeni kwesibopho se-glycosidic.

Le nhlanganisela ivame ukusetshenziswa ekwakhiweni kwama-glycoconjugates, ama-glycopeptides, nama-glycolipids. Inikeza indlela eguquguqukayo nephumelelayo yokuguqula ama-molecule anezinsalela ze-galactose, ezingaba usizo emikhakheni ehlukahlukene, kufaka phakathi izifundo zezinto eziphilayo, izinhlelo zokulethwa kwemithi, noma ukuthuthukiswa kwemithi yokugoma.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

I-Glycosylation: I-compound isabela nama-molecule ahlukahlukene e-acceptor aqukethe amaqembu e-hydroxyl, njenge-alcohols noma ama-amine, ukuze akhe izibopho ze-glycosidic. Lokhu kuvumela ukufakwa kwe-galactose ku-molecule ye-acceptor, okuholela ekuhlanganisweni kwama-glycoconjugates, ama-glycopeptides, noma ama-glycolipids.

Izifundo ze-biochemical kanye ne-biological: Le nhlanganisela isiza abacwaningi ukuthi bafunde imisebenzi ye-biological kanye nokusebenzisana kwama-molecule aqukethe i-galactose. Ngokunamathisela i-galactose ngokukhetha kumaprotheni, ama-peptide, noma amanye ama-biomolecule, abacwaningi bangaphenya izindima zabo ezinqubweni zamaseli, ukusebenzisana kwama-receptor-ligand, kanye nezinqubo zesifo.

Izinhlelo zokulethwa kwemithi: Le nhlanganisela ingasetshenziswa ukuguqula ama-molecule emithi anezinsalela ze-galactose, okwenza kube lula ukulethwa kwemithi eqondiwe ezicutshini noma emaseli athile. I-Galactose ingasebenza njenge-ligand eqondisa, iqaphela ama-receptor athile avela ebusweni bamaseli, ikakhulukazi ama-hepatocytes. Ngokunamathisela i-galactose emithini, abacwaningi bangathuthukisa ukukhetha kwabo kanye nokusebenza kahle ekwelashweni okuqondisiwe.

Ukuthuthukiswa kwemithi yokugoma: Ama-molecule aqukethe i-Galactose adlala indima ebalulekile ekuphenduleni kwamasosha omzimba, njengoba ebonakala ngama-lectin akhona kumaseli omzimba. Ngokuhlanganisa ama-antigen nezingxenye ze-galactose besebenzisa le nhlanganisela, abacwaningi bangathuthukisa izimpendulo zamasosha omzimba futhi bathuthukise imithi yokugoma esebenza kahle.

Ukwenziwa kwamakhemikhali: Le nhlanganisela ingasetshenziswa ekwakhiweni kwamakhemikhali ahlukahlukene lapho kudingeka khona ukuguqulwa kwe-galactose. Lokhu kufaka phakathi ukulungiswa kwezakhiwo eziyinkimbinkimbi zama-carbohydrate, ama-oligosaccharides, noma ama-glycomimetics, angasetshenziswa kabanzi kumakhemikhali ezokwelapha noma njengamathuluzi ocwaningo.

Isampula Yomkhiqizo

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C16H20Cl3NO10
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe
Inombolo ye-CAS	86520-63-0
Ukupakisha	Encane futhi enkulu
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.