I-CAS engu-2,2,2-Trifluoroacetamid:354-38-1

I-2,2,2-Trifluoroacetamide, eyaziwa nangokuthi i-trifluoroacetamide, iyi-crystalline eqinile engenambala ebonakala ngephunga layo elibukhali nelinolaka. Ngefomula yamakhemikhali i-CF3CONH2, idlala indima ebalulekile kumakhemikhali ezinto eziphilayo, ithola ukusetshenziswa kuzo zonke izimboni ezahlukene. Izakhiwo i-2,2,2-Trifluoroacetamide ineqembu le-trifluoromethyl (-CF3) elinamathele kumgogodla we-acetamide. Lokhu kwakheka kwesakhiwo kuthonya izakhiwo zayo zomzimba nezamakhemikhali. Ikhona njenge-crystalline eqinile engenambala, encibilika kancane emanzini kodwa incibilika kalula ezinyibilikeni zezinto eziphilayo njenge-acetone ne-ether. Inendawo yokuncibilika ezungeze ama-72°C. Isebenzisa Iqembu Elivikelayo Ekuhlanganisweni Kwe-Peptide: Enye yezicelo eziyinhloko ze-2,2,2-trifluoroacetamide njengeqembu elivikela ama-amine ekuhlanganisweni kwe-peptide. Ngokuvimba iqembu elisebenzayo le-amine, ivimbela ukusabela okungafuneki okungafuneki, okuvumela ukwakheka kwesibopho se-peptide esikhethiwe. Ukuhlanganiswa Kwamakhemikhali: I-compound isebenza njengebhloko yokwakha eguquguqukayo ekuhlanganisweni kwezinto eziphilayo. Isetshenziswa ekukhiqizweni kwemithi, amakhemikhali ezolimo, kanye namakhemikhali akhethekile ngenxa yokusabela kwayo okuhlukile kwamakhemikhali kanye nokuqina. I-solvent: I-Trifluoroacetamide isetshenziswa njengesinyibilikisi ezinqubweni ezahlukahlukene zamakhemikhali, okwenza kube lula ukuncibilika kanye nokuphathwa kwezinto ezisetshenziswayo ezimbonini ezahlukene. I-Synthesis 2,2,2-Trifluoroacetamide ingakhiwa ngezindlela eziningana. Enye indlela evamile ihilela ukusabela phakathi kwe-trifluoroacetic acid kanye ne-ammonia, okukhiqiza i-trifluoroacetamide kanye namanzi njengomkhiqizo olandelanayo. Ukusabela kuvame ukwenziwa ngaphansi kwezimo ezilawulwayo ukuqinisekisa ubumsulwa obuphezulu kanye nokukhiqiza. Ekuphetheni, i-2,2,2-trifluoroacetamide iyinhlanganisela eguquguqukayo esetshenziswa kabanzi ekuhlanganiseni izinto eziphilayo, ikakhulukazi kumakhemikhali e-peptide. Izakhiwo zayo ezihlukile kanye nokusabela kwamakhemikhali kwenza kube yinto ebalulekile ezimbonini ezahlukene, kufaka phakathi imithi, amakhemikhali ezolimo, kanye namakhemikhali akhethekile, lapho ifaka isandla ekuhlanganisweni kwemikhiqizo ehlukahlukene.