I-2-Amino-3-(4-hydroxyphenyl)propanoic acid CAS:556-03-6

I-2-Amino-3-(4-hydroxyphenyl)propanoic acid, eyaziwa nangokuthi i-L-DOPA noma i-levodopa, iyisandulela se-amino acid se-dopamine, i-neurotransmitter ehilelekile emisebenzini eyahlukene yomzimba, okuhlanganisa ukulawula ukunyakaza, ukulawulwa kwemizwa, kanye nezinhlelo zomvuzo. I-L-DOPA isetshenziswa kakhulu njengomuthi wokwelapha isifo sikaParkinson, isifo esiwohloka kobuchopho esibonakala ngokuntuleka kwe-dopamine ebuchosheni. Ngokuvamile inikezwa ngokuhlanganiswa ne-peripheral decarboxylase inhibitor ukuvimbela ukuguqulwa kwayo ibe yi-dopamine ngaphandle kobuchopho. I-L-DOPA ingasiza ekunciphiseni izimpawu zokunyakaza zesifo sikaParkinson, njengokuthuthumela, ukuqina, kanye ne-bradykinesia.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

Umphumela Esifweni SikaParkinson: I-L-DOPA umuthi osebenza kahle kakhulu ekwelapheni isifo sikaParkinson. Isifo sikaParkinson sibangelwa ukuntuleka kwe-dopamine ezindaweni ezithile zobuchopho. I-L-DOPA iyisandulela se-dopamine futhi inganqamula isithiyo segazi nobuchopho ukuze inyuse amazinga e-dopamine, ngaleyo ndlela inciphise izimpawu zesifo.

Ukusetshenziswa Kwezokwelapha Isifo SikaParkinson: I-L-DOPA ivame ukusetshenziswa kanye ne-peripheral decarboxylase inhibitor (njenge-carbidopa) ukuze kuthuthukiswe ukusebenza kwayo. I-decarboxylase inhibitor ivimbela ukuguqulwa kwe-L-DOPA ibe yi-dopamine ezicutshini zangaphandle, okuvumela i-L-DOPA eyengeziwe ukuthi ifinyelele ebuchosheni.

Ukuphathwa Kwezimpawu Zezinzwa: I-L-DOPA isiza ekunciphiseni izimpawu zenzwa ezihlobene nesifo sikaParkinson, okuhlanganisa ukuthuthumela, ukuqina, i-bradykinesia (ukuhamba kancane), kanye nokungazinzi kwesimo. Ithuthukisa ukusebenza kwenzwa futhi ivumela iziguli ukuthi ziphinde zilawule ukunyakaza kwazo.

Imiphumela Engemihle: Nakuba i-L-DOPA ivame ukusebenza kahle ekuphatheni izimpawu zikaParkinson, ingaholela nemiphumela eminingana emibi. Lokhu kungafaka phakathi i-dyskinesias (ukunyakaza okungahleliwe), izinkinga zesisu (njengokucanuzela kwenhliziyo, ukuhlanza, nokuqunjelwa), umfutho wegazi ophansi, ukubona izinto ezingekho, kanye nokushintsha kwemizwelo. Imiphumela emibi ingahluka ngobukhulu futhi idinga ukuqapha ngokucophelela nokulungiswa komthamo wemithi.

Ezinye Izindlela Zokusebenzisa: Ngaphandle kokwelashwa kwesifo sikaParkinson, i-L-DOPA iye yahlolwa kwezinye izindlela zokusebenzisa. Ibonise amandla ekuphathweni kwe-restless leg syndrome, isifo esibonakala ngesifiso sokuhambisa imilenze, okuholela ekungakhululeki kanye nobunzima bokulala. I-L-DOPA ingaba nomphumela omuhle ezinhlotsheni ezithile ze-dystonia, isifo sokunyakaza kwezinzwa.

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C9H11NO3
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe
Inombolo ye-CAS	556-03-6
Ukupakisha	Encane futhi enkulu
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.